Laboratory of Vector Control Research, Institute Pasteur of Guadeloupe, Lieu-dit Morne Jolivière, 97139, Les Abymes, Guadeloupe, France.
TERRA, Gembloux Agro-Bio Tech, University of Liège, Avenue de la Faculté 2B, 5030, Gembloux, Belgium.
Parasit Vectors. 2022 Jun 25;15(1):228. doi: 10.1186/s13071-022-05337-0.
In the fight against mosquito-borne diseases, odour-based lures targeting gravid females represent a promising alternative to conventional tools for both reducing mosquito populations and monitoring pathogen transmission. To be sustainable and effective, they are expected to use semiochemicals that act specifically against the targeted vector species. In control programmes directed against Aedes aegypti, several candidates of different origins (conspecifics, plants) have already been identified as potential oviposition attractants or repellents in laboratory experiments. However, few of these candidates have received validation in field experiments, studies depicting the active molecules and their mode of perception are still scarce, and there are several methodological challenges (i.e. lack of standardization, differences in oviposition index interpretation and use) that should be addressed to ensure a better reproducibility and accelerate the validation of candidates. In this review, we address the state of the art of the compounds identified as potential candidates for trap development against Ae. aegypti and their level of validation. We also offer a critical methodological analysis, highlight remaining gaps and research priorities, and propose a workflow to validate these candidates and to increase the panel of odours available to specifically trap Ae. aegypti.
在对抗蚊媒疾病的斗争中，针对妊娠雌蚊的气味引诱剂代表了一种有前途的替代传统工具的方法，可用于减少蚊子数量和监测病原体传播。为了实现可持续性和有效性，它们有望使用专门针对目标传播媒介物种的信息素。在针对埃及伊蚊的控制计划中，已经在实验室实验中鉴定出几种不同来源（同种、植物）的候选物作为潜在的产卵引诱剂或驱避剂。然而，这些候选物中很少有在现场实验中得到验证，描述活性分子及其感知模式的研究仍然很少，并且存在几个方法学挑战（即缺乏标准化、产卵指数解释和使用的差异），需要解决这些挑战，以确保更好的重现性并加速候选物的验证。在这篇综述中，我们介绍了被确定为针对埃及伊蚊开发诱捕器的潜在候选物的化合物的最新进展及其验证水平。我们还进行了批判性的方法学分析，突出了仍然存在的差距和研究重点，并提出了一个工作流程来验证这些候选物，并增加专门诱捕埃及伊蚊的气味的选择。
