Coffey R J, Go V L, Zinsmeister A R, DiMagno E P
Pancreas. 1986;1(1):55-61. doi: 10.1097/00006676-198601000-00011.
The effects of coffee on exocrine pancreatic secretion are unknown but may be important, because a link between chronic stimulation of pancreatic secretion and experimental chemical carcinogenesis and an association between coffee drinking and human pancreatic adenocarcinoma have been reported. We measured exocrine pancreatic trypsin and gastric acid secretions collected through orogastroduodenal tubes and serum gastrin in eight non-coffee drinkers and eight coffee drinkers. During fasting, after one interdigestive cycle control period, one of four 250-ml samples [plain water, water plus caffeine (4.6 mg/kg), decaffeinated coffee (127.9 mg/kg), caffeinated coffee (127.9 mg/kg)] was administered through the orogastric tube. Caffeinated and decaffeinated coffee (p = 0.008), caffeine (p = 0.03), and an unidentified substance(s) in coffee other than caffeine (p = 0.008) were associated with increased interdigestive exocrine pancreatic trypsin secretion. In addition, we also confirmed that coffee and caffeine stimulated gastric acid secretion (p = 0.02) and decaffeinated coffee raised serum gastrin concentrations (p = 0.005). If an association between coffee and pancreatic carcinogenesis exists, chronic stimulation of the exocrine pancreas by secretagogues could result in a gland susceptible to carcinogenesis.
咖啡对外分泌性胰腺分泌的影响尚不清楚，但可能很重要，因为已有报道称胰腺分泌的慢性刺激与实验性化学致癌作用之间存在联系，且喝咖啡与人类胰腺腺癌之间也有关联。我们测量了8名不喝咖啡者和8名喝咖啡者通过口胃十二指肠管收集的外分泌性胰腺胰蛋白酶和胃酸分泌以及血清胃泌素水平。在禁食期间，经过一个消化间期控制期后，通过口胃管给予四个250毫升样本之一[纯水、加咖啡因的水（4.6毫克/千克）、脱咖啡因咖啡（127.9毫克/千克）、含咖啡因咖啡（127.9毫克/千克）]。含咖啡因咖啡和脱咖啡因咖啡（p = 0.008）、咖啡因（p = 0.03）以及咖啡中除咖啡因外的一种未鉴定物质（p = 0.008）与消化间期外分泌性胰腺胰蛋白酶分泌增加有关。此外，我们还证实咖啡和咖啡因刺激胃酸分泌（p = 0.02），脱咖啡因咖啡可提高血清胃泌素浓度（p = 0.005）。如果咖啡与胰腺癌发生之间存在关联，那么促分泌剂对外分泌胰腺的慢性刺激可能会导致该腺体易发生癌变。
