Chuang Brandon J, Campellone Timothy R, Woolley Joshua D
University of California, Berkeley Department of Psychology, Berkeley, CA, USA.
San Francisco VA Medical Center, San Francisco, CA, USA.
Compr Psychoneuroendocrinol. 2020 Sep 19;4:100011. doi: 10.1016/j.cpnec.2020.100011. eCollection 2020 Nov.
Schizophrenia-spectrum disorders (SSD) are associated with deficits in emotional prosody recognition. Whether administration of oxytocin can improve emotional prosody recognition accuracy in SSD is unknown. Sixty individuals with SSD and ninety-seven controls completed a placebo-controlled, double-blind, cross-over trial examining the effects of oxytocin on emotional prosody recognition accuracy. Compared to controls, SSD was associated with poorer emotional prosody recognition accuracy, regardless of stimulus valence or intensity, suggesting a generalized deficit. Oxytocin had no effect on emotional prosody recognition in either group, which is consistent with previous work suggesting that oxytocin only improves high-level social cognition in SSD.
精神分裂症谱系障碍（SSD）与情绪韵律识别缺陷有关。催产素的施用是否能提高SSD患者的情绪韵律识别准确性尚不清楚。60名SSD患者和97名对照者完成了一项安慰剂对照、双盲、交叉试验，研究催产素对情绪韵律识别准确性的影响。与对照组相比，无论刺激效价或强度如何，SSD患者的情绪韵律识别准确性较差，提示存在普遍缺陷。催产素对两组的情绪韵律识别均无影响，这与之前的研究结果一致，即催产素仅能改善SSD患者的高级社会认知。
