Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy.
Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy.
Clin Neurophysiol. 2022 Aug;140:126-135. doi: 10.1016/j.clinph.2022.05.017. Epub 2022 Jun 15.
To disentangle the pathophysiology of cognitive/affective impairment in Coronavirus Disease-2019 (COVID-19), we studied long-term cognitive and affective sequelae and sleep high-density electroencephalography (EEG) at 12-month follow-up in people with a previous hospital admission for acute COVID-19.
People discharged from an intensive care unit (ICU) and a sub-intensive ward (nonICU) between March and May 2020 were contacted between March and June 2021. Participants underwent cognitive, psychological, and sleep assessment. High-density EEG recording was acquired during a nap. Slow and fast spindles density/amplitude/frequency and source reconstruction in brain gray matter were extracted. The relationship between psychological and cognitive findings was explored with Pearson correlation.
We enrolled 33 participants ( 17 nonICU) and 12 controls. We observed a lower Physical Quality of Life index, higher post-traumatic stress disorder (PTSD) score, and a worse executive function performance in nonICU participants. Higher PTSD and Beck Depression Inventory scores correlated with lower executive performance. The same group showed a reorganization of spindle cortical generators.
Our results show executive and psycho-affective deficits and spindle alterations in COVID-19 survivors - especially in nonICU participants - after 12 months from discharge.
These findings may be suggestive of a crucial contribution of stress experienced during hospital admission on long-term cognitive functioning.
为了厘清 2019 年冠状病毒病（COVID-19）患者认知/情感障碍的病理生理学，我们研究了先前因急性 COVID-19 住院的患者在 12 个月随访时的长期认知和情感后遗症以及睡眠高密度脑电图（EEG）。
在 2020 年 3 月至 5 月期间，我们联系了从重症监护病房（ICU）和亚重症病房（非 ICU）出院的患者。参与者接受了认知、心理和睡眠评估。在小睡期间进行高密度 EEG 记录。提取脑灰质中慢和快纺锤波的密度/幅度/频率和源重建。使用 Pearson 相关探索心理和认知发现之间的关系。
我们招募了 33 名参与者（17 名非 ICU）和 12 名对照。我们观察到非 ICU 参与者的身体质量指数较低、创伤后应激障碍（PTSD）评分较高和执行功能较差。较高的 PTSD 和贝克抑郁量表评分与较差的执行表现相关。同一组显示出纺锤皮层发生器的重组。
我们的结果表明，COVID-19 幸存者在出院后 12 个月出现执行和心理情感缺陷以及纺锤波改变 - 尤其是非 ICU 参与者。
这些发现可能表明住院期间经历的压力对长期认知功能有重要贡献。
