Pagheh Abdol Sattar, Asghari Arghavan, Abrari Romenjan Khadijeh, Mousavi Tahoora, Abedi Farshid, Ziaee Arash, Malakimoghadam Hakime, Ziaee Masood
Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Iran J Microbiol. 2022 Apr;14(2):138-144. doi: 10.18502/ijm.v14i2.9178.
Health care workers (HCWs) are a high-risk group for acquiring and transmitting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Aim of the study was the evaluation of seroprevalence of SARS-CoV-2 in a random sample of HCWs at a large acute care hospital in Iran.
We collected blood samples of 180 medical staffs from September 22, 2020 to January 26, 2021. The enzyme linked immunosorbent assays (ELISA) tests were used for evaluation of the presence of IgG antibodies. Participants completed a self-report questionnaire, comprising demographics, occupational, the work area, and personal protection data.
Of the 180 HCWs who participated in this study, 44 (24.4%) were seropositive for anti-SARS-CoV-2 IgG. The percentage of IgG positivity was higher in males than females (P<0.05). Also, there was statistically significant difference between presence of the antibodies and the occupation, location, and infecting family members with Covid -1 (P<0.05). Other factors did not associate significantly to antibody presence against SARS-CoV-2 (P>0.05).
According to this point that the number of COVID-19 cases is still growing rapidly among HCWs. So, the epidemiological estimate of SARS-CoV-2 infection remains a major challenge that is needed to prevent the spread of infection in the hospitals.
医护人员是感染和传播严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的高危人群。本研究的目的是评估伊朗一家大型急症医院随机抽取的医护人员样本中SARS-CoV-2的血清阳性率。
我们于2020年9月22日至2021年1月26日采集了180名医护人员的血样。采用酶联免疫吸附测定（ELISA）检测来评估IgG抗体的存在情况。参与者完成了一份自我报告问卷，内容包括人口统计学、职业、工作区域和个人防护数据。
在参与本研究的180名医护人员中，44人（24.4%）抗SARS-CoV-2 IgG血清学呈阳性。男性的IgG阳性率高于女性（P<0.05）。此外，抗体的存在与职业、工作地点以及是否有感染新冠病毒的家庭成员之间存在统计学显著差异（P<0.05）。其他因素与抗SARS-CoV-2抗体的存在无显著关联（P>0.05）。
鉴于医护人员中新冠病毒疾病（COVID-19）病例数仍在迅速增加。因此，SARS-CoV-2感染的流行病学评估仍然是一项重大挑战，这对于预防医院内感染传播至关重要。
