Department of Optometry, Baekseok Culture University, Cheonan, 31065, Korea.
Department of Optometry, Division of Health Science, and Graduate School of Health and Welfare, Baekseok University, Cheonan, 31065, Korea.
Sci Rep. 2022 Jun 30;12(1):11046. doi: 10.1038/s41598-022-14167-0.
Dry eye disease (DED) is a multifactorial disease of the ocular surface causing severe discomfort, mild ocular irritation, fatigue, pain, visual disturbance, and foreign body sensation. Stress, depression, and sleep disorders are risk factors for DED. We aimed to investigate the association between DED symptoms and composite factors related to mental health (combined sleep duration, psychological stress perception, and history of depressed mood) in Korean adults aged ≥ 20 years in a population-based study using the 2010-2012 Korea National Health and Nutrition Examination Survey data. Symptoms of DED and data on mental health were obtained using questionnaires. Multiple logistic regression analysis was conducted to examine the association between mental health and DED, and adjusted for possible covariates. Subjects with symptoms of DED were more likely to experience short sleep duration, psychological stress perception, and a history of depressed mood [odds ratio (OR) = 1.42, 95% confidence interval (CI) 1.06-1.90; OR = 1.71, 95% CI 1.37-2.14; and OR = 1.37, 95% CI 1.06-1.77, respectively] even after correcting for demographic factors, lifestyle factors, and medical factors. Additionally, participants with symptoms of DED were more likely to experience composite factors related to mental health (OR = 1.91, 95% CI 1.07-3.39). Therefore, ophthalmologists may report difficulties in both sleep and mental health in patients with DED.
干眼症（DED）是一种多因素的眼表疾病，可导致严重不适、轻度眼部刺激、疲劳、疼痛、视觉障碍和异物感。压力、抑郁和睡眠障碍是 DED 的危险因素。我们旨在研究在一项基于人群的研究中，韩国≥20 岁成年人的 DED 症状与心理健康相关的综合因素（合并睡眠时间、心理压力感知和抑郁情绪史）之间的关联，该研究使用了 2010-2012 年韩国国家健康和营养检查调查数据。DED 症状和心理健康数据是通过问卷调查获得的。采用多因素逻辑回归分析来研究心理健康与 DED 之间的关联，并对可能的混杂因素进行调整。有 DED 症状的受试者更有可能经历睡眠时间短、心理压力感知和抑郁情绪史[比值比（OR）=1.42，95%置信区间（CI）1.06-1.90；OR=1.71，95%CI 1.37-2.14；OR=1.37，95%CI 1.06-1.77，分别]，即使在纠正了人口统计学因素、生活方式因素和医疗因素后也是如此。此外，有 DED 症状的参与者更有可能经历与心理健康相关的综合因素（OR=1.91，95%CI 1.07-3.39）。因此，眼科医生可能会报告 DED 患者在睡眠和心理健康方面都存在困难。
