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与SARS-CoV-2感染相关的动静脉并发血栓形成应如何处理?

How Should Concurrent Arterial and Venous Thrombosis Associated With SARS-CoV-2 Infection Be Managed?

作者信息

Dimosiari Athina, Patoulias Dimitrios, Michailidis Theodoros, Dimitroulas Theodoros

机构信息

Department of Emergency Medicine, General Hospital of Kozani, Kozani, Greece.

Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, General Hospital "Hippokration", Thessaloniki, Greece.

出版信息

Eur J Case Rep Intern Med. 2022 May 17;9(5):003366. doi: 10.12890/2022_003366. eCollection 2022.

DOI:10.12890/2022_003366
PMID:35774738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9239018/
Abstract

UNLABELLED

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is associated with a high incidence of thrombotic complications involving both the arterial and the venous systems. However, concurrent arterial and venous thrombosis is extremely rare. Herein, we present the case of a 75-year-old male patient with severe COVID-19 who developed bilateral renal artery thrombosis and pulmonary embolism during the disease course. To our knowledge, this is the first such case described in the literature.

LEARNING POINTS

SARS-CoV-2-related coagulopathy is associated with both arterial and venous thrombotic events, which increase morbidity and mortality.Concurrent arterial and venous thrombotic events attributed to SARS-CoV-2 are extremely rare.A high index of clinical suspicion is required, while further research is needed to determine the optimal type, dose and duration of anticoagulation in such cases.

摘要

未标注

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是2019冠状病毒病(COVID-19)的病原体,与涉及动脉和静脉系统的血栓形成并发症的高发生率相关。然而,同时发生动脉和静脉血栓形成极为罕见。在此,我们报告一例75岁男性重症COVID-19患者,其在病程中发生双侧肾动脉血栓形成和肺栓塞。据我们所知,这是文献中描述的首例此类病例。

学习要点

SARS-CoV-2相关凝血病与动脉和静脉血栓形成事件均相关,这会增加发病率和死亡率。由SARS-CoV-2引起的同时发生的动脉和静脉血栓形成事件极为罕见。需要高度的临床怀疑指数,同时需要进一步研究以确定此类病例中抗凝的最佳类型、剂量和持续时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3487/9239018/b286e7179c4a/3366_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3487/9239018/68bb8da042e7/3366_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3487/9239018/b286e7179c4a/3366_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3487/9239018/68bb8da042e7/3366_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3487/9239018/b286e7179c4a/3366_Fig2.jpg

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Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.COVID-19 患者的抗凝治疗:JACC 本周专题评论
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Eur Heart J Case Rep. 2020 Nov 17;4(6):1-6. doi: 10.1093/ehjcr/ytaa350. eCollection 2020 Dec.
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Immunity, endothelial injury and complement-induced coagulopathy in COVID-19.COVID-19 中的免疫、内皮损伤和补体诱导的凝血异常。
Nat Rev Nephrol. 2021 Jan;17(1):46-64. doi: 10.1038/s41581-020-00357-4. Epub 2020 Oct 19.
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Thromb Res. 2020 Jul;191:148-150. doi: 10.1016/j.thromres.2020.04.041. Epub 2020 Apr 30.
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