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Oligoclonal T-cell expansion in a patient with bone marrow failure after CD19 CAR-T therapy for Richter-transformed DLBCL.

作者信息

Rejeski Kai, Wu Zhijie, Blumenberg Viktoria, Kunz Wolfgang G, Müller Susanna, Kajigaya Sachiko, Gao Shouguo, Bücklein Veit L, Frölich Lisa, Schmidt Christian, von Bergwelt-Baildon Michael, Feng Xingmin, Young Neal S, Subklewe Marion

机构信息

Department of Medicine III, Hematology/Oncology, University Hospital, Ludwig-Maximilians Universität (LMU) Munich, Munich, Germany.

Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany.

出版信息

Blood. 2022 Nov 17;140(20):2175-2179. doi: 10.1182/blood.2022017015.

DOI:10.1182/blood.2022017015
PMID:35776908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9837444/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6805/9837444/8742aca0b2a8/BLOOD_BLD-2022-017015-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6805/9837444/a03214b663e5/BLOOD_BLD-2022-017015-fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6805/9837444/c928f3449c26/BLOOD_BLD-2022-017015-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6805/9837444/8742aca0b2a8/BLOOD_BLD-2022-017015-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6805/9837444/a03214b663e5/BLOOD_BLD-2022-017015-fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6805/9837444/c928f3449c26/BLOOD_BLD-2022-017015-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6805/9837444/8742aca0b2a8/BLOOD_BLD-2022-017015-gr2.jpg

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The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL.嵌合抗原受体 T 细胞(CAR-T)治疗后复发/难治性大 B 细胞淋巴瘤(R/R LBCL)患者的 CAR-HEMATOTOX 风险可预测严重感染和疾病进展。
J Immunother Cancer. 2022 May;10(5). doi: 10.1136/jitc-2021-004475.
2
Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.单细胞 RNA 测序与大颗粒淋巴细胞白血病 T 细胞 TCR 谱分析的结合。
Nat Commun. 2022 Apr 11;13(1):1982. doi: 10.1038/s41467-022-29175-x.
3
Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma.
由大颗粒淋巴细胞驱动的嵌合抗原受体 T 细胞治疗后出现严重血细胞减少并对类固醇有反应。
Br J Haematol. 2025 Jan;206(1):180-185. doi: 10.1111/bjh.19822. Epub 2024 Oct 19.
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Mechanisms and management of CAR T toxicity.嵌合抗原受体T细胞毒性的机制与管理
Front Oncol. 2024 May 21;14:1396490. doi: 10.3389/fonc.2024.1396490. eCollection 2024.
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Immune effector cell-associated haematotoxicity after CAR T-cell therapy: from mechanism to management.嵌合抗原受体 T 细胞(CAR T)治疗后与免疫效应细胞相关的血液毒性:从机制到管理。
Lancet Haematol. 2024 Jun;11(6):e459-e470. doi: 10.1016/S2352-3026(24)00077-2. Epub 2024 May 8.
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Int J Mol Sci. 2024 Feb 19;25(4):2416. doi: 10.3390/ijms25042416.
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