Li Qian, Li Ji-Jun, Bao Xing-Hui, Zhang Shi-Yu, Luo Qin, Li Ke-Ming, Jiao Ya-Bing, Cheng Yong-Xian, Yan Yong-Ming
Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China.
Clinical Lab, Shenzhen University General Hospital, Shenzhen 518055, PR China.
Bioorg Chem. 2022 Oct;127:105986. doi: 10.1016/j.bioorg.2022.105986. Epub 2022 Jun 26.
Sinkianlignans A - D (1-4), four new sesquilignans with an unusual architectures was characterized with a rarely α-γ', β-γ', and γ-γ' linkage pattern, and sinkianlignans E - F (5 and 6), two lignans, were isolated from the Ferula sinkiangensis. Hypothetic biosynthetic pathway of compound 3 contain a newly formed six-membered C-ring by Diels-Alder cycloaddition. The structures of isolates were established by spectroscopic techniques and computational methods. Biological evaluation of all the isolated compounds revealed that compounds 2a and 2b could inhibit IL-6 and TNF-α production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose-dependent manner.
新源木脂素A - D（1 - 4）是四种具有不寻常结构的新倍半木脂素，其具有罕见的α-γ'、β-γ'和γ-γ'连接模式，新源木脂素E - F（5和6）是两种木脂素，它们从新疆阿魏中分离得到。化合物3的推测生物合成途径包含通过狄尔斯-阿尔德环加成反应新形成的六元C环。通过光谱技术和计算方法确定了分离物的结构。对所有分离化合物的生物学评价表明，化合物2a和2b可以剂量依赖性方式抑制脂多糖（LPS）诱导的RAW264.7细胞中IL-6和TNF-α的产生。
