• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新疆阿魏树脂中的消旋新木脂素及其对 COX-2 的抑制活性。

Racemic norneolignans from the resin of Ferula sinkiangensis and their COX-2 inhibitory activity.

机构信息

Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, PR China.

Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, PR China.

出版信息

Fitoterapia. 2023 Jan;164:105341. doi: 10.1016/j.fitote.2022.105341. Epub 2022 Oct 27.

DOI:10.1016/j.fitote.2022.105341
PMID:36309142
Abstract

Five new norneolignans sinkianlignans G-K (1-5), one phenolic compound ferulagenol A (6) and seven known compounds (7-13) were isolated from Ferula sinkiangensis. All the norneolignans were racemic mixtures, and chiral HPLC was used to further separate them. Their structures were assigned, including absolute configurations, using spectroscopic and computational methods. Biological evaluation showed that compounds 1-9 had significant COX-2 inhibitory activity with IC values ranging from 3.00 μM to 23.19 μM.

摘要

从新疆阿魏中分离得到了五个新的正木脂素（1-5）、一个酚类化合物阿魏酸松柏醇 A（6）和七个已知化合物（7-13）。所有的正木脂素均为外消旋混合物，采用手性 HPLC 进一步分离。通过光谱和计算方法确定了它们的结构，包括绝对构型。生物评价结果表明，化合物 1-9 对 COX-2 具有显著的抑制活性，IC 值范围为 3.00 μM 至 23.19 μM。

相似文献

1
Racemic norneolignans from the resin of Ferula sinkiangensis and their COX-2 inhibitory activity.新疆阿魏树脂中的消旋新木脂素及其对 COX-2 的抑制活性。
Fitoterapia. 2023 Jan;164:105341. doi: 10.1016/j.fitote.2022.105341. Epub 2022 Oct 27.
2
Racemic Norlignans as Diastereoisomers from Resins with Antitumor and Wound-Healing Promotion Activities.具有抗肿瘤和促进伤口愈合活性的树脂中的外消旋去甲二氢愈创木酸作为非对映异构体。
Molecules. 2022 Jun 17;27(12):3907. doi: 10.3390/molecules27123907.
3
Unusual sesquilignans with anti-inflammatory activities from the resin of Ferula sinkiangensis.从新疆阿魏树脂中分离得到的具有抗炎活性的罕见倍半木脂素。
Bioorg Chem. 2022 Oct;127:105986. doi: 10.1016/j.bioorg.2022.105986. Epub 2022 Jun 26.
4
Bioactive sesquiterpene coumarins from the resin of Ferula sinkiangensis targeted on over-activation of microglia.靶向小胶质细胞过度激活的新疆阿魏树脂中生物活性倍半萜香豆素。
Bioorg Chem. 2020 Nov;104:104338. doi: 10.1016/j.bioorg.2020.104338. Epub 2020 Oct 8.
5
New Sulfoxide-Containing Derivatives from the Resin of Ferula sinkiangensis.新疆阿魏树脂中的含亚砜新衍生物。
Planta Med. 2022 May;88(6):420-428. doi: 10.1055/a-1495-5963. Epub 2021 May 20.
6
An unusual sesquiterpene coumarin from the seeds of Ferula sinkiangensis.一种来自新疆阿魏种子的罕见倍半萜香豆素。
J Asian Nat Prod Res. 2016 Sep;18(9):891-6. doi: 10.1080/10286020.2016.1168813. Epub 2016 Apr 7.
7
Sesquiterpene coumarins from seeds of Ferula sinkiangensis.新疆阿魏种子中的倍半萜香豆素
Fitoterapia. 2015 Jun;103:222-6. doi: 10.1016/j.fitote.2015.03.022. Epub 2015 Mar 27.
8
Steroidal esters from Ferula sinkiangensis.新疆阿魏中的甾体酯类化合物。
Fitoterapia. 2014 Sep;97:247-52. doi: 10.1016/j.fitote.2014.06.016. Epub 2014 Jun 28.
9
Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima.新疆阿魏和托里阿魏根中的倍半萜香豆素
Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1595-8. doi: 10.1248/cpb.54.1595.
10
Sesquiterpene coumarins from Ferula sinkiangensis K.M.Shen and their cytotoxic activities.新疆阿魏中的倍半萜香豆素及其细胞毒活性。
Phytochemistry. 2020 Dec;180:112531. doi: 10.1016/j.phytochem.2020.112531. Epub 2020 Sep 30.

引用本文的文献

1
New Ethylated Derivatives of Sulfur- and Nitrogen-Containing Artifacts from Egg Pod and Their Anti-Renal Fibrosis.从鸡蛋果中提取的含硫和氮的新型乙基化衍生物及其抗肾纤维化作用。
Molecules. 2024 Jul 25;29(15):3491. doi: 10.3390/molecules29153491.
2
A Comprehensive Review of the Pharmacological Effects of Genus Ferula on Central Nervous System Disorders.综述：阿魏属植物对中枢神经系统紊乱的药理作用。
Cent Nerv Syst Agents Med Chem. 2024;24(2):105-116. doi: 10.2174/0118715249256485231031043722.
3
Sesquiterpenes and Sesquiterpene Derivatives from : Their Chemical Structures, Biosynthetic Pathways, and Biological Properties.
来自[具体来源未给出]的倍半萜及其衍生物：它们的化学结构、生物合成途径和生物学特性。
Antioxidants (Basel). 2023 Dec 19;13(1):7. doi: 10.3390/antiox13010007.
4
Isolation, Identification, Anti-Inflammatory, and In Silico Analysis of New Lignans from the Resin of .从……树脂中分离、鉴定新木脂素及其抗炎作用和计算机模拟分析
Pharmaceuticals (Basel). 2023 Sep 25;16(10):1351. doi: 10.3390/ph16101351.
5
(Chou-AWei, Chinese ): Traditional Uses, Phytoconstituents, Biosynthesis, and Pharmacological Activities.（周-阿魏，中文）：传统用途、植物成分、生物合成及药理活性。
Plants (Basel). 2023 Feb 16;12(4):902. doi: 10.3390/plants12040902.