Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
Changping Laboratory, Beijing, China.
Neuroimage. 2022 Oct 1;259:119420. doi: 10.1016/j.neuroimage.2022.119420. Epub 2022 Jun 29.
Multimodal neuroimaging plays an important role in neuroscience research. Integrated noninvasive neuroimaging modalities, such as magnetoencephalography (MEG), electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS), allow neural activity and related physiological processes in the brain to be precisely and comprehensively depicted, providing an effective and advanced platform to study brain function. Noncryogenic optically pumped magnetometer (OPM) MEG has high signal power due to its on-scalp sensor layout and enables more flexible configurations than traditional commercial superconducting MEG. Here, we integrate OPM-MEG with EEG and fNIRS to develop a multimodal neuroimaging system that can simultaneously measure brain electrophysiology and hemodynamics. We conducted a series of experiments to demonstrate the feasibility and robustness of our MEG-EEG-fNIRS acquisition system. The complementary neural and physiological signals simultaneously collected by our multimodal imaging system provide opportunities for a wide range of potential applications in neurovascular coupling, wearable neuroimaging, hyperscanning and brain-computer interfaces.
多模态神经影像学在神经科学研究中发挥着重要作用。集成的无创神经影像学模式，如脑磁图（MEG）、脑电图（EEG）和功能近红外光谱（fNIRS），可以精确和全面地描绘大脑中的神经活动和相关生理过程，为研究大脑功能提供了一个有效和先进的平台。由于其头皮传感器布局，非低温光泵磁强计（OPM）MEG 具有高信号功率，并且可以比传统的商业超导 MEG 实现更灵活的配置。在这里，我们将 OPM-MEG 与 EEG 和 fNIRS 集成在一起，开发了一种可以同时测量脑电生理学和血液动力学的多模态神经影像学系统。我们进行了一系列实验，以证明我们的 MEG-EEG-fNIRS 采集系统的可行性和稳健性。我们的多模态成像系统同时采集的互补神经和生理信号为神经血管耦合、可穿戴神经影像学、超扫描和脑机接口等广泛的潜在应用提供了机会。
