Research and Development section, Noble Pharma LLC, 4602 Domain Drive, Menomonie, WI, USA.
Research and Development section, Noble Pharma LLC, 4602 Domain Drive, Menomonie, WI, USA.
J Trace Elem Med Biol. 2022 Sep;73:127023. doi: 10.1016/j.jtemb.2022.127023. Epub 2022 Jun 20.
Curcumin, a polyphenolic compound isolated from turmeric rhizome, displays antioxidant, anti-inflammatory, anticancer, anti-microbial, antiviral, antidiabetic, neuroprotective, immune boosting and other chemopreventive and therapeutic properties. However, the efficacy of curcumin is confined due to its aqueous insolubility, instability, low intestinal absorption, poor bioavailability, and systemic elimination. Therefore, to overcome these issues and enhance pharmacological activities of curcumin, a complex of curcumin with metals such as zinc have been synthesized. Curcumin acts as a ligand and forms a stable complex with zinc. In this review, the improved protective, and therapeutic activities of zinc-curcumin complexes are discussed. Zinc-curcumin conjugates have exhibited enhanced antioxidant, anti-inflammatory, anticancer, antimicrobial and antidiabetic properties. Zinc-curcumin complexes have also displayed hepatoprotective, gastroprotective, neuroprotective, cardioprotective and osteogenesis efficacy. These protective and therapeutic efficacies of zinc-curcumin conjugates were associated with modulation of multiple molecular mechanisms including decreased inflammatory cytokines, increased antioxidant enzymes, quenched free radicals, decreased blood glucose levels, decreased insulin resistance, induced apoptosis markers, and restored function of tumor suppressor protein p53 in cancer cells. Overall, applications of zinc-curcumin complex could be a new approach against various diseases and could also be helpful in improvement of health.
姜黄素是从姜黄根茎中分离得到的一种多酚化合物，具有抗氧化、抗炎、抗癌、抗菌、抗病毒、抗糖尿病、神经保护、免疫增强等化学预防和治疗特性。然而，由于其在水中的不溶性、不稳定性、低肠道吸收、生物利用度差和全身消除，姜黄素的疗效受到限制。因此，为了克服这些问题并增强姜黄素的药理活性，已经合成了姜黄素与锌等金属的复合物。姜黄素作为配体与锌形成稳定的配合物。在这篇综述中，讨论了锌-姜黄素复合物的改善的保护和治疗活性。锌-姜黄素缀合物表现出增强的抗氧化、抗炎、抗癌、抗菌和抗糖尿病特性。锌-姜黄素配合物还显示出肝保护、胃保护、神经保护、心脏保护和成骨作用。锌-姜黄素缀合物的这些保护和治疗功效与多种分子机制的调节有关，包括减少炎症细胞因子、增加抗氧化酶、清除自由基、降低血糖水平、降低胰岛素抵抗、诱导细胞凋亡标志物以及恢复肿瘤抑制蛋白 p53 在癌细胞中的功能。总的来说，锌-姜黄素复合物的应用可能是治疗各种疾病的新方法，也有助于改善健康。
