Nath Rajat, Das Chandrima, Kityania Sibashish, Nath Deepa, Das Subrata, Choudhury Manabendra Dutta, Patra Jayanta Kumar, Talukdar Anupam Das
Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India.
Department of Botany, Guru Charan College, Silchar, Assam, India.
Comb Chem High Throughput Screen. 2023;26(5):863-879. doi: 10.2174/1386207325666220701121537.
Deadly disease cancer has many types; among them, lung cancer is responsible for the highest number of cancer mortality. Existing therapies as well as drugs for treating lung cancer are not effective and are often associated with innumerable side effects and toxicities. For these reasons, researchers have been working on developing novel anti-cancer medicines from plants and other natural sources that have a high safety profile. Natural flavonoids are a polyphenolic group of phytochemicals extracted from plants and other plant-derived compounds. Natural flavonoids are gaining popularity due to their unique and priceless medicinal properties, including anticancer properties. Several researchers have already declared that flavonoids possess the ability to treat different cancers, particularly lung cancer. The bioactivity of natural flavonoids is mainly due to their structural diversity. Natural flavonoids fight against lung cancer by regulating redox homeostasis, upregulating apoptosis, pro-apoptotic factors, and survival genes, arresting cell cycle progression, autophagy, reducing cell proliferation and invasiveness, maintaining inflammation response, downregulating anti-apoptotic factors, and targeting lung cancer signaling pathways. Flavonoids can act alone or synergistically with other agents to treat lung cancer. Due to these reasons, it is possible to use natural flavonoids as pharmaceutical leads to prevent and treat lung cancer.
致命疾病癌症有多种类型；其中，肺癌导致的癌症死亡人数最多。现有的肺癌治疗方法和药物效果不佳，且常常伴有无数的副作用和毒性。基于这些原因，研究人员一直在致力于从植物和其他天然来源开发具有高安全性的新型抗癌药物。天然黄酮类化合物是从植物和其他植物衍生化合物中提取的一类多酚类植物化学物质。天然黄酮类化合物因其独特且珍贵的药用特性（包括抗癌特性）而越来越受到关注。几位研究人员已经宣称黄酮类化合物具有治疗不同癌症，尤其是肺癌的能力。天然黄酮类化合物的生物活性主要归因于其结构多样性。天然黄酮类化合物通过调节氧化还原稳态、上调细胞凋亡、促凋亡因子和存活基因、阻止细胞周期进程、自噬、减少细胞增殖和侵袭性、维持炎症反应、下调抗凋亡因子以及靶向肺癌信号通路来对抗肺癌。黄酮类化合物可以单独发挥作用，也可以与其他药物协同作用来治疗肺癌。基于这些原因，有可能将天然黄酮类化合物用作药物先导物来预防和治疗肺癌。
