Bird A G, Lendrum R, Asherson R A, Hughes G R
Ann Rheum Dis. 1987 Mar;46(3):251-5. doi: 10.1136/ard.46.3.251.
A middle aged woman presented with acute, severe, intravascular coagulation leading to ischaemic necrosis of the extremities. Pulmonary involvement required artificial ventilation, and there was evidence of hepatic, pancreatic, and renal damage, which resolved without complication. These events may have been triggered by the ingestion of compound diuretic tablets. The finding of the 'lupus anticoagulant' and anticardiolipin antibodies, together with high titre antinuclear factor in the serum, and antibodies to extractable nuclear antigen (RNP), and a past history of spontaneous abortion, suggest that this was a dramatic manifestation of an immune connective tissue disorder.
一名中年女性出现急性、严重的血管内凝血，导致肢体缺血性坏死。肺部受累需要人工通气，并有肝、胰和肾损伤的证据，但这些损伤均无并发症地得以恢复。这些情况可能是由服用复方利尿片引发的。血清中发现“狼疮抗凝物”和抗心磷脂抗体，以及高滴度抗核因子、可提取核抗原（RNP）抗体，还有既往自然流产史，提示这是免疫性结缔组织病的一种严重表现。
