Byrd B F, Hartmann W H, Graham L S, Hogle H H
Ann Surg. 1987 May;205(5):529-32. doi: 10.1097/00000658-198705000-00011.
A type of mastopathy is unique to insulin-dependent diabetic patients. The characteristic change is a connective tissue overgrowth with vasculitis and some proliferation of duct epithelium. It is not the type of change typically associated with an increased risk of breast cancer. Clinically this change is indistinguishable by physical or radiographic findings from breast malignancy. Eleven biopsies showing these characteristics were performed on insulin-dependent patients who had diabetes mellitus from childhood. Every patient had some major complication of diabetes mellitus, usually diabetic retinopathy. In every instance the mastopathy continued to manifest itself as a part of the healing process. The probability is that this is an evidence in the breast of collagen cross-linking changes seen in patients with diabetes mellitus. This observation should help in the supervision of patients with a clinical background compatible with this study.
一种乳腺病是胰岛素依赖型糖尿病患者所特有的。其特征性变化是结缔组织过度生长伴血管炎以及导管上皮的一些增生。这并非通常与乳腺癌风险增加相关的那种变化类型。临床上，这种变化在体格检查或影像学检查结果上与乳腺恶性肿瘤难以区分。对11名自幼患有糖尿病的胰岛素依赖型患者进行了显示这些特征的活检。每位患者都有一些糖尿病的主要并发症，通常是糖尿病视网膜病变。在每种情况下，这种乳腺病都持续表现为愈合过程的一部分。很可能这是糖尿病患者乳腺中所见胶原交联变化的一个证据。这一观察结果应有助于对具有与本研究相符临床背景的患者进行监测。
