Department of Integrated Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
J Zhejiang Univ Sci B. 2022 Jul 15;23(7):547-563. doi: 10.1631/jzus.B2101019.
Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths. Surgery, radiotherapy, chemotherapy, immunotherapy, and endocrine therapy are currently the main treatments for this cancer type. However, some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy, resulting in limited treatment efficacy. Consequently, traditional Chinese medicinal materials (TCMMs) as natural products have become an attractive source of novel drugs. In this review, we summarized the current knowledge on the active components of animal-derived TCMMs, including derived cordycepin, the aqueous and ethanolic extracts of , norcantharidin (NCTD), Chansu, bee venom, deer antlers, , and scorpion venom, with reference to marked anti-breast cancer effects due to regulating cell cycle arrest, proliferation, apoptosis, metastasis, and drug resistance. In future studies, the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies. Furthermore, large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment.
乳腺癌是全球女性最常见的侵袭性癌症，仍然是癌症相关死亡的主要原因之一。手术、放疗、化疗、免疫疗法和内分泌疗法是目前治疗这种癌症类型的主要方法。然而，一些乳腺癌患者容易对化疗或免疫疗法产生耐药性，导致治疗效果有限。因此，作为天然产物的中药（TCMMs）已成为新型药物的有吸引力的来源。在这篇综述中，我们总结了动物源性 TCMMs 的活性成分的最新知识，包括来源于虫草素、西红花酸、去甲斑蝥素（NCTD）、蟾酥、蜂毒、鹿角、全蝎毒液的水提物和醇提物，这些成分由于调节细胞周期停滞、增殖、凋亡、转移和耐药性而具有显著的抗乳腺癌作用。在未来的研究中，需要利用多组学技术进一步研究这些成分的抗肿瘤作用的潜在机制。此外，还需要进行大规模的临床试验来验证这些生物活性成分单独或与化疗药物联合治疗乳腺癌的疗效。
