Jamall I S, Haldar D, Wadewitz A G
Biochem Biophys Res Commun. 1987 Apr 29;144(2):815-20. doi: 10.1016/s0006-291x(87)80037-2.
Male, weanling myopathic Syrian Golden Hamsters (BIO 14.6 strain) were fed a selenium-adequate diet (controls) or this diet supplemented with 1.0 ppm selenium (treated) for 30 days. Se-treated animals exhibited a 50% reduction in lipid peroxidation in heart homogenates relative to controls and a 61% increase in mitochondrial glycerophosphate acyltransferase activity. Gel electrophoresis revealed no alterations in cardiac protein profiles from treated or control animals. These data suggest that the selenium prevents peroxidative injury and maintains mitochondrial function in the absence of alterations in cardiac proteins.
雄性断奶期患肌病的叙利亚金仓鼠（BIO 14.6品系）被喂食含充足硒的饲料（对照组）或添加了1.0 ppm硒的该饲料（处理组），持续30天。与对照组相比，经硒处理的动物心脏匀浆中的脂质过氧化水平降低了50%，线粒体甘油磷酸酰基转移酶活性增加了61%。凝胶电泳显示，处理组和对照组动物的心脏蛋白质谱没有变化。这些数据表明，在心脏蛋白质没有改变的情况下，硒可预防过氧化损伤并维持线粒体功能。
