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锌（II）配位驱动的自组装纳米剂用于多模态成像引导的光热/基因协同治疗。

Zn(ii)-Coordination-driven self-assembled nanoagents for multimodal imaging-guided photothermal/gene synergistic therapy.

作者信息

Hu Hui, Yang Nan, Sun Jiahui, Zhou Fu, Gu Rui, Liu Yuan, Wang Li, Song Xuejiao, Yun Ruirui, Dong Xiaochen, Wang Guangfeng

机构信息

Key Laboratory of Chem-Biosensing of Anhui Province, Key Laboratory of Functional Molecular Solids, College of Chemistry and Materials Science, Anhui Normal University Wuhu 241000 Anhui Province China

Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech) Nanjing 211816 China

出版信息

Chem Sci. 2022 Jun 2;13(24):7355-7364. doi: 10.1039/d2sc01769e. eCollection 2022 Jun 22.

DOI:10.1039/d2sc01769e
PMID:35799809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9214881/
Abstract

Synergistic photothermal therapy (PTT) with gene therapy (GT) has drawn emerging interest in the improvement of cancer therapeutic efficiency, while the co-delivery of photothermal agents (PTAs) and therapeutic genes by an integrated nanoplatform, with controllability and biodegradability, is still challenging and urgently desired. Herein, a multi-functional metal-organic framework (MOF) based PTT-GT platform (siRNA@PT-ZIF-8) was developed, which was constructed with siRNA, a near-infrared (NIR) responsive organic dye IR780 derivative (IR780-1), and 2-methylimidazole (2-MIM) by a facile one-pot self-assembly method. This "all-in-one" system of siRNA@PT-ZIF-8 enabled not only photothermal/photoacoustic/fluorescence multimodal imaging but also tumor microenvironment responsiveness for specific and on-demand release of therapeutic cargos, overcoming the inherent limitations of free gene or organic PTA molecules (, short blood circulation half-life and weak stability) in conventional PTT and GT. This nanoplatform provides an efficient and safe strategy for cancer theranostics, and the one-step assembly strategy favors personalized formulation design for diverse demands in cancer management.

摘要

光热疗法（PTT）与基因疗法（GT）协同作用在提高癌症治疗效率方面引起了新的关注，然而，通过具有可控性和可生物降解性的集成纳米平台共同递送光热剂（PTA）和治疗性基因仍然具有挑战性且迫切需要。在此，开发了一种基于多功能金属有机框架（MOF）的PTT-GT平台（siRNA@PT-ZIF-8），它通过简便的一锅自组装方法由siRNA、近红外（NIR）响应有机染料IR780衍生物（IR780-1）和2-甲基咪唑（2-MIM）构建而成。这种siRNA@PT-ZIF-8的“一体化”系统不仅能够实现光热/光声/荧光多模态成像，还具有肿瘤微环境响应性，可用于治疗性货物的特异性和按需释放，克服了传统PTT和GT中游离基因或有机PTA分子固有的局限性（血液循环半衰期短和稳定性差）。这种纳米平台为癌症诊疗提供了一种高效且安全的策略，并且一步组装策略有利于针对癌症管理中的各种需求进行个性化制剂设计。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/986c67176542/d2sc01769e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/6514f33126fc/d2sc01769e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/5ef6a2945ed1/d2sc01769e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/7576d05d4bea/d2sc01769e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/06a3226a00db/d2sc01769e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/1d5fb2666ff4/d2sc01769e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/986c67176542/d2sc01769e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/6514f33126fc/d2sc01769e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/5ef6a2945ed1/d2sc01769e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/7576d05d4bea/d2sc01769e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/06a3226a00db/d2sc01769e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/1d5fb2666ff4/d2sc01769e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7569/9214881/986c67176542/d2sc01769e-f5.jpg

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1
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Nat Rev Drug Discov. 2021 Nov;20(11):817-838. doi: 10.1038/s41573-021-00283-5. Epub 2021 Aug 25.
2
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Angew Chem Int Ed Engl. 2021 Sep 20;60(39):21200-21204. doi: 10.1002/anie.202107036. Epub 2021 Aug 17.
3
A Borondifluoride-Complex-Based Photothermal Agent with an 80 % Photothermal Conversion Efficiency for Photothermal Therapy in the NIR-II Window.
Bufalin-Loaded Multifunctional Photothermal Nanoparticles Inhibit the Anaerobic Glycolysis by Targeting SRC-3/HIF-1α Pathway for Improved Mild Photothermal Therapy in CRC.
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Int J Nanomedicine. 2024 Aug 1;19:7831-7850. doi: 10.2147/IJN.S470005. eCollection 2024.
4
Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells.用于活细胞中APE1的灵敏检测和细胞内成像的DNA网络的靶向介导自组装。
Chem Sci. 2023 Feb 10;14(9):2318-2324. doi: 10.1039/d2sc06968g. eCollection 2023 Mar 1.
5
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Cancers (Basel). 2022 Aug 15;14(16):3935. doi: 10.3390/cancers14163935.
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Angew Chem Int Ed Engl. 2020 Dec 7;59(50):22537-22543. doi: 10.1002/anie.202003653. Epub 2020 Sep 30.
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