Gennari-Felipe Matheus, Borges Leandro, Dermargos Alexandre, Weimann Eleine, Curi Rui, Pithon-Curi Tania Cristina, Hatanaka Elaine
Instituto de Ciências da Atividade Física e Esportes, Universidade Cruzeiro do Sul, São Paulo, Brazil.
Seção de Produção de Imunobiológicos, Centro Bioindustrial, Instituto Butantan, São Paulo, Brazil.
Front Med (Lausanne). 2022 Jun 21;9:917008. doi: 10.3389/fmed.2022.917008. eCollection 2022.
Coronavirus disease 2019 (COVID-19) features hyper-inflammation, cytokine storm, neutrophil function changes, and sodium chloride (NaCl) homeostasis disruption, while the treatment with NaCl hypertonic solutions (HS) controls electrolytic body homeostasis and cell functions. HS treatment is a simple, popular, economic, and feasible therapy to regulate leukocyte function with a robust anti-inflammatory effect in many inflammatory diseases. The purpose of this narrative review is to highlight the knowledge on the use of HS approaches against viral infection over the past years and to describe the mechanisms involved in the release of neutrophil extracellular traps (NETs) and production of cytokine in severe lung diseases, such as COVID-19. We reported the consequences of hyponatremia in COVID-19 patients, and the immunomodulatory effects of HS, either or . We also described the relationship between electrolyte disturbances and COVID-19 infection. Although there is still a lack of clinical trials, hypertonic NaCl solutions have marked effects on neutrophil function and NETs formation, emerging as a promising adjuvant therapy in COVID-19.
2019冠状病毒病（COVID-19）的特征为炎症反应过度、细胞因子风暴、中性粒细胞功能改变以及氯化钠（NaCl）体内稳态破坏，而使用高渗氯化钠溶液（HS）进行治疗可控制机体电解质稳态及细胞功能。HS治疗是一种简单、常用、经济且可行的疗法，可调节白细胞功能，在许多炎症性疾病中具有强大的抗炎作用。本叙述性综述的目的是强调过去几年中关于使用HS方法对抗病毒感染的知识，并描述严重肺部疾病（如COVID-19）中中性粒细胞胞外陷阱（NETs）释放和细胞因子产生所涉及的机制。我们报告了COVID-19患者低钠血症的后果，以及HS（无论是否 ）的免疫调节作用。我们还描述了电解质紊乱与COVID-19感染之间的关系。尽管仍缺乏临床试验，但高渗氯化钠溶液对中性粒细胞功能和NETs形成具有显著影响，正在成为COVID-19中一种有前景的辅助治疗方法。
