Database Center for Life Science, Joint Support-Center for Data Science Research, Research Organization of Information and Systems, University of Tokyo Kashiwanoha-campus Station Satellite 6F, Kashiwa, Chiba 277-0871, Japan.
Bioinformatics. 2022 Sep 2;38(17):4194-4199. doi: 10.1093/bioinformatics/btac491.
Understanding life cannot be accomplished without making full use of biological data, which are scattered across databases of diverse categories in life sciences. To connect such data seamlessly, identifier (ID) conversion plays a key role. However, existing ID conversion services have disadvantages, such as covering only a limited range of biological categories of databases, not keeping up with the updates of the original databases and outputs being hard to interpret in the context of biological relations, especially when converting IDs in multiple steps.
TogoID is an ID conversion service implementing unique features with an intuitive web interface and an application programming interface (API) for programmatic access. TogoID currently supports 65 datasets covering various biological categories. TogoID users can perform exploratory multistep conversions to find a path among IDs. To guide the interpretation of biological meanings in the conversions, we crafted an ontology that defines the semantics of the dataset relations.
The TogoID service is freely available on the TogoID website (https://togoid.dbcls.jp/) and the API is also provided to allow programmatic access. To encourage developers to add new dataset pairs, the system stores the configurations of pairs at the GitHub repository (https://github.com/togoid/togoid-config) and accepts the request of additional pairs.
Supplementary data are available at Bioinformatics online.
如果不能充分利用生物数据，就无法全面了解生命，而这些数据分散在生命科学的各个数据库中。为了实现数据的无缝连接，标识符 (ID) 转换发挥着关键作用。然而，现有的 ID 转换服务存在一些缺点，例如只涵盖了数据库中有限的生物类别范围，无法跟上原始数据库的更新，并且在生物学关系的上下文中，输出结果难以解释，尤其是在进行多步 ID 转换时。
TogoID 是一种 ID 转换服务，它具有直观的网络界面和应用程序编程接口 (API)，可实现独特的功能，用于进行编程访问。TogoID 目前支持涵盖各种生物类别的 65 个数据集。TogoID 用户可以执行探索性的多步转换，以在 ID 之间找到一条路径。为了指导在转换过程中对生物学意义的解释，我们构建了一个本体，定义了数据集关系的语义。
TogoID 服务可在 TogoID 网站（https://togoid.dbcls.jp/）上免费使用，并且还提供了 API 以允许进行编程访问。为了鼓励开发人员添加新的数据集对，系统将在 GitHub 存储库（https://github.com/togoid/togoid-config）中存储对的配置，并接受添加对的请求。
补充数据可在 Bioinformatics 在线获取。
