White M I, Jenkinson D M, Lloyd D H
Br J Dermatol. 1987 Apr;116(4):525-30. doi: 10.1111/j.1365-2133.1987.tb05873.x.
The thickness of, and number of cell layers in, the stratum corneum and the living epidermis were determined on frozen sections of washed and unwashed skin from normal and atopic individuals of both sexes. The stratum corneum of atopic patients was thinner and had fewer layers of dead cells and intercellular lipid than normal, although the living epidermis was thicker. Regular washing with soap and water had no appreciable effect on the dimensions of the living epidermis of either group but caused a reduction in the number of cell layers and the amount of sudanophilic material in the stratum corneum of both. In atopic patients little surface lipid remained, suggesting that washing with soap and water may be detrimental to the barrier function of the stratum corneum in such patients.
对来自正常和特应性的男女个体的清洗和未清洗皮肤的冰冻切片，测定了角质层的厚度和细胞层数以及活表皮的细胞层数。特应性患者的角质层比正常人更薄，死细胞层和细胞间脂质更少，尽管活表皮更厚。用肥皂和水定期清洗对两组的活表皮尺寸没有明显影响，但导致两组角质层的细胞层数和嗜苏丹物质数量减少。在特应性患者中，几乎没有表面脂质残留，这表明用肥皂和水清洗可能对这类患者的角质层屏障功能有害。
