Nabi Masarat, Zargar Mohammed Iqbal, Tabassum Nahida, Ganai Bashir Ahmad, Wani Shahid Ud Din, Alshehri Sultan, Alam Prawez, Shakeel Faiyaz
Department of Environmental Science, University of Kashmir, Srinagar 190006, Jammu & Kashmir, India.
Department of Pharmaceutical Sciences, University of Kashmir, Srinagar 190006, Jammu & Kashmir, India.
Plants (Basel). 2022 Jun 23;11(13):1667. doi: 10.3390/plants11131667.
is a plant species native to the Western Himalaya region that has tremendous potential for phytochemical activities. This study aimed to identify bioactive compounds and assess the antibacterial activity of . To determine the major bioactive chemicals in the methanol leaf extract of , we used a gas chromatography-mass spectrometer (GC-MS). The presence of 35 distinct phytoconstituents was discovered using GC-MS, which could contribute to the therapeutic capabilities of this plant species. The most predominant compound was 2R-acetoxymethyl-1,3,3-trimethyl-4t-(3-methyl-2-buten-1-yl)-1t-cyclohexanol (23.9%). Further, the leaf extract was evaluated for antibacterial activity against , , , , and . The extract showed the highest zone of inhibition against (19 mm) followed by (18 mm) and (17 mm) at 160 mg mL. The minimum inhibitory concentration (MIC) of methanol extract against the strain of (2 mg mL) demonstrated significant antibacterial activity. The findings of the present study highlight the potential of for the development of herbal medicines for the treatment of various pathogenic infections.
是一种原产于喜马拉雅山西部地区的植物物种，具有巨大的植物化学活性潜力。本研究旨在鉴定生物活性化合物并评估其抗菌活性。为了确定该植物甲醇叶提取物中的主要生物活性化学成分，我们使用了气相色谱 - 质谱联用仪（GC - MS）。通过GC - MS发现了35种不同的植物成分，这些成分可能有助于该植物物种的治疗能力。最主要的化合物是2R - 乙酰氧基甲基 - 1,3,3 - 三甲基 - 4t - （3 - 甲基 - 2 - 丁烯 - 1 - 基） - 1t - 环己醇（23.9%）。此外，还评估了叶提取物对、、、和的抗菌活性。在160 mg/mL时，提取物对的抑菌圈最大（19 mm），其次是（18 mm）和（17 mm）。甲醇提取物对菌株的最低抑菌浓度（MIC）为（2 mg/mL），显示出显著的抗菌活性。本研究结果突出了该植物在开发用于治疗各种致病性感染的草药方面的潜力。
