Nabi Masarat, Tabassum Nahida, Ganai Bashir Ahmad
Department of Environmental Science, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Front Plant Sci. 2022 Jul 29;13:930687. doi: 10.3389/fpls.2022.930687. eCollection 2022.
N.P. Taylor and Airy Shaw (Rutaceae) is a perennial, aromatic, gregarious wild ornamental shrub native to the Western Himalaya. The plant is used in the traditional medicinal system to treat copious health conditions like rheumatism, fever, inflammation, headache, influenza, body-ache, clearing of the nose, diabetes, lowering the body temperature, smallpox, wounds, burns, snake, and scorpion bites. Phytochemical and gas chromatography-mass spectrometer (GC-MS) analysis of showed the presence of alkanes, alkenes, carboxylic acids, fatty acids, and their esters, simple coumarins, terpenes, phenylpropanoid, and so on. These active principles exhibit a wide array of pharmacological effects, including anti-inflammatory, antioxidant, anti-cancerous, anti-feedant, and antibacterial properties. Most pharmacological studies were based on the essential oil and the crude extracts of the plant and the bioactive compounds responsible for the bioefficacy have not been well-identified. Further investigations are required to transform the experience-based claims on the use of in traditional medicine practices into evidence-based information. Detailed and studies on the mechanisms of action of pure bioactive compounds and more elaborate toxicity studies to ensure plant safety for human use should be conducted. This review recapitulates the current status of its use in the ethnobotany, phytochemistry, and pharmacological activities. It also offers a critical assessment of the plant's existing information which would help to recuperate its potential as a source for drug development of lead molecules.
N.P.泰勒和艾里·肖（芸香科）是一种多年生、芳香、群居的野生观赏灌木，原产于喜马拉雅山西部。该植物在传统医学体系中用于治疗多种健康问题，如风湿病、发烧、炎症、头痛、流感、身体疼痛、鼻塞、糖尿病、降低体温、天花、伤口、烧伤、蛇咬和蝎子蜇伤。对其进行的植物化学和气相色谱 - 质谱联用（GC - MS）分析表明存在烷烃、烯烃、羧酸、脂肪酸及其酯类、简单香豆素、萜类、苯丙素类等。这些活性成分具有广泛的药理作用，包括抗炎、抗氧化、抗癌、抗摄食和抗菌特性。大多数药理研究基于该植物的精油和粗提物，而对产生生物功效的生物活性化合物尚未明确鉴定。需要进一步研究，将传统医学实践中基于经验的关于该植物用途的说法转化为基于证据的信息。应开展关于纯生物活性化合物作用机制的详细研究以及更详尽的毒性研究，以确保该植物对人类使用的安全性。本综述概述了其在民族植物学、植物化学和药理活性方面的应用现状。它还对该植物的现有信息进行了批判性评估，这将有助于恢复其作为先导分子药物开发来源的潜力。
