泽兰苦内酯和丹参醛苷A，具有来自孔氏泽兰叶的抗菌和抗炎作用。
Eupatorin and Salviandulin-A, with Antimicrobial and Anti-Inflammatory Effects from Kunth Leaves.
作者信息
González-Cortazar Manasés, Salinas-Sánchez David Osvaldo, Herrera-Ruiz Maribel, Román-Ramos Dionisio Celerino, Zamilpa Alejandro, Jiménez-Ferrer Enrique, Ble-González Ever A, Álvarez-Fitz Patricia, Castrejón-Salgado Ricardo, Pérez-García Ma Dolores
机构信息
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico.
Centro de Investigación en Biodiversidad y Conservación (CIByC), Universidad Autónoma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico.
出版信息
Plants (Basel). 2022 Jun 30;11(13):1739. doi: 10.3390/plants11131739.
This study describes the antimicrobial and anti-inflammatory effects from extracts obtained from the leaves of Salvia lavanduloides. The plant material was macerated with three solvents of ascending polarity (n-hexane (Sl-Hex), ethyl acetate (Sl-AcOEt), and dichloromethane (Sl-D)). The extracts, fractions (SlD-2 and SlD-3), and isolated compounds (15,16-epoxy-10-β-hydroxy-neo-cleroda-3,7,13(16),14-tetraene-17,12R:18,19-diolide (1), salviandulin A (2), and eupatorin (3)) were evaluated as antimicrobials against Gram-negative, Gram-positive bacteria and the fungus Candida albicans (Ca) using the minimum inhibitory concentration (MIC) and the anti-inflammatory activity induced by 13-acetate of 12-O-tetradecanoylforbol (TPA). Sl-D and Sl-AcOEt extracts, SlD-2 and SlD-3 fractions showed the highest antimicrobial activity. The isolated compounds showed good activity against Pseudomonas aeruginosa with a MIC < 2 μg/mL, while the anti-inflammatory activity, the Sl-Hex, Sl-D extracts, and SlD-3 fraction presented an inhibition of 62, 45 and 61%, respectively, while (2) 70% and (3) 72%.
本研究描述了从薰衣草叶中提取的提取物的抗菌和抗炎作用。将植物材料用三种极性递增的溶剂（正己烷（Sl-Hex）、乙酸乙酯（Sl-AcOEt）和二氯甲烷（Sl-D））进行浸渍。对提取物、馏分（SlD-2和SlD-3）以及分离出的化合物（15,16-环氧-10-β-羟基-新克罗烷-3,7,13(16),14-四烯-17,12R:18,19-二内酯（1）、丹参二醇A（2）和泽兰黄素（3）），使用最低抑菌浓度（MIC）评估其对革兰氏阴性菌、革兰氏阳性菌和白色念珠菌（Ca）的抗菌活性，以及对12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的抗炎活性。Sl-D和Sl-AcOEt提取物、SlD-2和SlD-3馏分显示出最高的抗菌活性。分离出的化合物对铜绿假单胞菌显示出良好的活性，MIC < 2 μg/mL，而抗炎活性方面，Sl-Hex、Sl-D提取物和SlD-3馏分的抑制率分别为62%、45%和61%，而（2）为70%，（3）为72%。
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