Ovchinnikov Aleksandr N, Deryugina Anna V, Paoli Antonio
Department of Sports Medicine and Psychology, Lobachevsky University, Nizhny Novgorod, Russia.
Department of Physiology and Anatomy, Lobachevsky University, Nizhny Novgorod, Russia.
Front Nutr. 2022 Jun 23;9:893515. doi: 10.3389/fnut.2022.893515. eCollection 2022.
This study aimed to examine whether oral royal jelly (RJ) and coenzyme Q10 (CoQ10) co-supplementation could improve high-intensity interval exercise (HIIE) performance in runners, reducing exercise-induced lactic acidosis and decreasing elevated sympathetic tone following exercise.
Thirty regional-level runners (age: 19 ± 1 years; height: 173 ± 2 cm; body mass: 68.9 ± 2 kg; body mass index: 23.1 ± 1 kg/m) were randomly allocated to receive either 400 mg of RJ and 60 mg of CoQ10 (RJQ) or matching placebo (PLA) once daily for 10 days. Exercise performance expressed as time taken to complete HIIE was evaluated at baseline, and then reassessed at day 10 of intervention. HIIE protocol applied to the runners included three repetitions of 100 m distance at maximum possible speed interspersed with 45 s of recovery periods. Indices of heart rate variability and blood lactate concentration were also measured before and immediately after HIIE in each group.
HIIE performance significantly improved in RJQ group ( = 0.005) compared to PLA group. Blood lactate levels and sympathetic influence on the heart were significantly lower both before and after the HIIE in athletes who received RJQ ( < 0.05) compared to PLA. Regression analysis showed that oral RJQ administration for 10 days was significantly associated with reductions in HIIE-induced increases in blood lactate concentration and enhanced cardiac parasympathetic modulation following exercise compared to PLA. Principal component analysis revealed that runners treated with RJQ are grouped by the first two principal components into a separate cluster compared to PLA. Correlation analysis demonstrated that the improvements in runners' HIIE performance were due in significant part to RJQ-induced reduction of increment in blood lactate levels in response to exercise in combination with a more rapid shift in autonomic activity toward increased parasympathetic control early at post-exercise.
These findings suggest that RJQ supplementation for 10 days is potentially effective for enhancing HIIE performance and alleviating adverse effects of increased intramuscular acidity and prolonged sympathetic dominance following intense exercise.
本研究旨在探讨口服蜂王浆（RJ）和辅酶Q10（CoQ10）联合补充是否能提高跑步者的高强度间歇运动（HIIE）表现，减轻运动诱发的乳酸酸中毒，并降低运动后升高的交感神经张力。
30名地区级跑步者（年龄：19±1岁；身高：173±2厘米；体重：68.9±2千克；体重指数：23.1±1千克/平方米）被随机分配，每天接受一次400毫克RJ和60毫克CoQ10（RJQ）或匹配的安慰剂（PLA），持续10天。以完成HIIE所需时间表示的运动表现在基线时进行评估，然后在干预的第10天重新评估。应用于跑步者的HIIE方案包括以最大可能速度进行三次100米距离的重复，中间穿插45秒的恢复期。每组在HIIE之前和之后立即测量心率变异性和血乳酸浓度指标。
与PLA组相比，RJQ组的HIIE表现显著改善（P = 0.005）。与PLA相比，接受RJQ的运动员在HIIE之前和之后的血乳酸水平和交感神经对心脏的影响均显著降低（P < 0.05）。回归分析表明，与PLA相比，连续10天口服RJQ与HIIE诱发的血乳酸浓度升高的降低以及运动后心脏副交感神经调制增强显著相关。主成分分析显示，与PLA相比，接受RJQ治疗的跑步者在前两个主成分上被归为一个单独的聚类。相关分析表明，跑步者HIIE表现的改善在很大程度上归因于RJQ引起的运动后血乳酸水平升高的降低，以及运动后自主神经活动更快地向增加副交感神经控制转变。
这些发现表明，连续10天补充RJQ可能对提高HIIE表现以及减轻剧烈运动后肌肉酸度增加和交感神经长期主导的不良影响有效。
