应用振动控制瞬时弹性成像在美国人群中尿酸与肝脂肪变性和纤维化的相关性：一项全国性横断面研究。
Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study.
机构信息
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, China.
Department of Endocinology & Metabolic Diseases, Affiliated Hospital of Xiangnan University, Chenzhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Jun 23;13:930224. doi: 10.3389/fendo.2022.930224. eCollection 2022.
BACKGROUND AND OBJECTIVE
Serum uric acid (UA) is related to many metabolic diseases. However, the association of UA with liver diseases was not very clear. The objective of this study is to clarify the relationship of UA with liver steatosis and fibrosis.
METHODS
This is a cross-sectional study of 4364 people of National Health and Nutrition Examination Survey (NHANES) 2017-2018. Liver steatosis and fibrosis were assessed by controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) using Vibration-controlled transient elastography (VCTE). Linear and logistic regressions were performed.
RESULTS
After adjusting for potential confounders, UA levels were associated with the prevalence of liver steatosis [OR=2.097 (95%CI: 1.245, 3.534)] and liver fibrosis [OR=2.983 (95%CI: 1.797, 4.952)]. Furthermore, the results were consistent in the subgroup analyses of males and females.
CONCLUSIONS
UA levels were positively associated with the prevalence of liver steatosis and fibrosis.
背景和目的
血清尿酸（UA）与许多代谢性疾病有关。然而，UA 与肝脏疾病的关系尚不清楚。本研究旨在阐明 UA 与肝脂肪变性和纤维化的关系。
方法
这是一项横断面研究，纳入了 2017-2018 年国家健康和营养检查调查（NHANES）的 4364 人。采用受控衰减参数（CAP）和瞬时弹性成像（VCTE）测量肝脏硬度（LSM）评估肝脂肪变性和纤维化。采用线性和逻辑回归进行分析。
结果
在调整了潜在混杂因素后，UA 水平与肝脂肪变性的患病率相关[比值比（OR）=2.097（95%可信区间：1.245，3.534）]和肝纤维化[OR=2.983（95%可信区间：1.797，4.952）]。此外，在男性和女性的亚组分析中，结果一致。
结论
UA 水平与肝脂肪变性和纤维化的患病率呈正相关。
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