埃塞俄比亚东北 Raya Kobo 区确诊病例家庭和邻居中的无症状疟疾。

Asymptomatic Malaria in Households and Neighbors of Laboratory Confirmed Cases in Raya Kobo District, Northeast Ethiopia.

机构信息

Dessie Health Science College, Ethiopia.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, Ethiopia.

出版信息

Ethiop J Health Sci. 2022 May;32(3):623-630. doi: 10.4314/ejhs.v32i3.19.

DOI:10.4314/ejhs.v32i3.19

PMID:35813680

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9214748/

Abstract

BACKGROUND

Malaria is the leading vector-borne parasitic disease that is causing high morbidity and mortality worldwide. So far huge efforts to control and eliminate malaria are hindered by the occurrence of asymptomatic carriers that are a potential source of infection. Yet, there is a scarcity of data nationally and in the current study area as well. Therefore, this study was aimed to assess the prevalence of asymptomatic malaria in Northeast Ethiopia.

METHODS

A community-based cross-sectional study was conducted in 2019 involving a total of 270 study participants recruited via purposive non-probability sampling technique. A structured questionnaire was used to collect data on sociodemographic characteristics, individual and household factors related to asymptomatic malaria. Data were entered in Epi Data 3.1 version and analyzed by using SPSS version 20, and p< 0.05 was considered statistically significant.

RESULTS

The overall prevalence of asymptomatic malaria was 7.0%, with 3.0%, 5.2%, and 12.0%, respectively by Rapid diagnostic tests (RDT), Microscopy and Polymerase chain reaction (PCR). The majority of infections (73.7%) were identified from index households. Previous malaria history (AOR: 4.030, 95% CI: 1.021-15.903), living with index cases (AOR: 3.880, 95% CI: 1.275-11.806) and family size > 6 members (AOR: 4.820, 95% CI: 1.260-18.437) were significant predictors of asymptomatic malaria.

CONCLUSION

Reactive case detection had identified considerably higher asymptomatic malaria cases in the community. Therefore, active case investigation should be established in the community by tracking the symptomatic cases at the health facilities.

摘要

背景

疟疾是全球发病率和死亡率较高的主要虫媒寄生疾病。到目前为止，控制和消除疟疾的巨大努力受到无症状感染者的阻碍，他们是潜在的感染源。然而，全国和当前研究地区的数据仍然稀缺。因此，本研究旨在评估埃塞俄比亚东北部无症状疟疾的流行率。

方法

2019 年进行了一项基于社区的横断面研究，共纳入 270 名研究参与者，通过有目的的非概率抽样技术招募。使用结构化问卷收集与无症状疟疾相关的社会人口统计学特征、个体和家庭因素的数据。数据输入 Epi Data 3.1 版本，并使用 SPSS 版本 20 进行分析，p<0.05 被认为具有统计学意义。

结果

无症状疟疾的总患病率为 7.0%，快速诊断测试（RDT）、显微镜检查和聚合酶链反应（PCR）分别为 3.0%、5.2%和 12.0%。大多数感染（73.7%）来自索引家庭。既往疟疾史（AOR：4.030，95%CI：1.021-15.903）、与索引病例同住（AOR：3.880，95%CI：1.275-11.806）和家庭规模>6 人（AOR：4.820，95%CI：1.260-18.437）是无症状疟疾的显著预测因素。