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Gold mining nature for natural products: DNA sequencing and bioinformatics has reinvigorated the search for secondary metabolites for applications in medicine, agriculture and industry: DNA sequencing and bioinformatics has reinvigorated the search for secondary metabolites for applications in medicine, agriculture and industry.从天然产物到金矿：DNA 测序和生物信息学重新激发了寻找用于医学、农业和工业应用的次生代谢产物的研究。
EMBO Rep. 2022 Aug 3;23(8):e55697. doi: 10.15252/embr.202255697. Epub 2022 Jul 12.
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Natural product discovery: past, present, and future.天然产物的发现：过去、现在和未来。
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Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways.利用链霉菌 A3(2)基因组序列发现新的天然产物和生物合成途径。
J Ind Microbiol Biotechnol. 2014 Feb;41(2):219-32. doi: 10.1007/s10295-013-1383-2. Epub 2013 Dec 10.
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The evolution of genome mining in microbes - a review.微生物中基因组挖掘的演变——综述。
Nat Prod Rep. 2016 Aug 27;33(8):988-1005. doi: 10.1039/c6np00025h. Epub 2016 Jun 8.
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Genome mining for drug discovery: progress at the front end.基因组挖掘在药物发现中的应用：前端进展。
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Natural product discovery through microbial genome mining.通过微生物基因组挖掘发现天然产物。
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J Ind Microbiol Biotechnol. 2014 Feb;41(2):251-63. doi: 10.1007/s10295-013-1379-y. Epub 2013 Nov 21.
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The impact and prospect of natural product discovery in agriculture: New technologies to explore the diversity of secondary metabolites in plants and microorganisms for applications in agriculture.天然产物在农业中的影响和前景：探索植物和微生物中次生代谢产物多样性的新技术，应用于农业。
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Evolutionary concepts in natural products discovery: what actinomycetes have taught us.天然产物发现中的进化概念：放线菌教给我们的知识。
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本文引用的文献

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An epigenetic switch activates bacterial quorum sensing and horizontal transfer of an integrative and conjugative element.一个表观遗传开关激活了细菌群体感应和整合共轭元件的水平转移。
Nucleic Acids Res. 2022 Jan 25;50(2):975-988. doi: 10.1093/nar/gkab1217.
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Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture.通过共培养发现放线菌基因组中编码的新型次生代谢产物。
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Mycoremediation effect of Trichoderma harzianum strain T22 combined with ozonation in diesel-contaminated sand.哈茨木霉 T22 菌株与臭氧化联合作用对柴油污染砂的生物修复效果。
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Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.基于抗性基因的导向发现具有全新作用模式的天然产物型除草剂。
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Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.非培养依赖性发现马拉菌素作为钙依赖性抗生素，对多药耐药革兰氏阳性病原体具有活性。
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Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation.真菌与细菌共培养对新型微生物次级代谢产物的双重诱导
Front Microbiol. 2017 Jul 11;8:1284. doi: 10.3389/fmicb.2017.01284. eCollection 2017.
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Complete biosynthesis of opioids in yeast.酵母中阿片类药物的完整生物合成。
Science. 2015 Sep 4;349(6252):1095-100. doi: 10.1126/science.aac9373. Epub 2015 Aug 13.
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High-level semi-synthetic production of the potent antimalarial artemisinin.高效半合成制备强效抗疟药物青蒿素。
Nature. 2013 Apr 25;496(7446):528-32. doi: 10.1038/nature12051. Epub 2013 Apr 10.
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Big effects from small changes: possible ways to explore nature's chemical diversity.微小变化产生巨大影响：探索自然界化学多样性的可能途径。
Chembiochem. 2002 Jul 2;3(7):619-27. doi: 10.1002/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO;2-9.

从天然产物到金矿：DNA 测序和生物信息学重新激发了寻找用于医学、农业和工业应用的次生代谢产物的研究。

Gold mining nature for natural products: DNA sequencing and bioinformatics has reinvigorated the search for secondary metabolites for applications in medicine, agriculture and industry: DNA sequencing and bioinformatics has reinvigorated the search for secondary metabolites for applications in medicine, agriculture and industry.

机构信息

Freelance Journalist, London, UK.

出版信息

EMBO Rep. 2022 Aug 3;23(8):e55697. doi: 10.15252/embr.202255697. Epub 2022 Jul 12.

DOI:10.15252/embr.202255697
PMID:35822265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9346468/
Abstract

Natural products are highly sought after in medicine, agriculture, and industry. The challenge is to find these and their underlying biochemical pathways and genes.

摘要

天然产物在医学、农业和工业中备受追捧。挑战在于找到这些天然产物及其潜在的生化途径和基因。