Tunis Med. 2022;100(1):37-43.
The link between gastric mucosa-associated lymphoid tissue lymphoma (LG-MALT) and chronic Helicobacter Pylori (HP) infection had led to a real revolution in the management of the disease.
To study the results of the HP eradication therapy and to clarify its place in the tumor response.
A descriptive retrospective bicentric study, between January 2007 and December 2016, including patients with LG-MALT treated in the gastroenterology departments of Sahloul hospital in Sousse and Habib Bougtafa hospital in Bizerte, and having received treatment for eradication of HP.
Sixty-three patients were included. The male/female sex ratio was 1.42. The average age was 58 years. The symptomatology was dominated by epigastric pain (96.8%). On digestive endoscopy, the most frequent location and appearance were gastric antrum (39.6%) and ulcerations (89%). The lymphoma was classified as stage IE and IIE1 in 81% and 19% of cases, respectively. The HP status was positive in all patients. The HP eradication rate was 82.5% after three anti-HP treatment courses. Complete remission of lymphoma was obtained in 81% of patients at 18 months. Non-response to HP eradication therapy was observed in 19% of patients. Non-responder patients had a longer diagnostic delay (p=0.02), more diffuse endoscopic involvement (p=0.001) and a more frequent appearance of large gastric folds (p=0.001).
The course of LG-MALT is determined by the treatment for the eradication of HP. Its success promotes remission of lymphoma.
胃黏膜相关淋巴组织淋巴瘤（LG-MALT）与慢性幽门螺杆菌（HP）感染之间的联系，使得该疾病的治疗发生了真正的变革。
研究 HP 根除治疗的结果，并阐明其在肿瘤反应中的地位。
这是一项描述性的回顾性双中心研究，于 2007 年 1 月至 2016 年 12 月在苏塞的 Sahloul 医院和比塞大的 Habib Bougtafa 医院的胃肠病科进行，包括接受 HP 根除治疗的 LG-MALT 患者。
共纳入 63 例患者，男女比例为 1.42:1，平均年龄为 58 岁，症状主要为上腹痛（96.8%）。在消化内镜下，最常见的部位和表现为胃窦（39.6%）和溃疡（89%）。淋巴瘤分期分别为 IE 期和 IIE1 期，各占 81%和 19%。所有患者的 HP 状态均为阳性。经过三疗程抗 HP 治疗，HP 根除率为 82.5%。18 个月时，81%的患者淋巴瘤完全缓解。19%的患者对 HP 根除治疗无反应。无反应者的诊断延迟时间更长（p=0.02），内镜下受累更广泛（p=0.001），大胃皱襞更常见（p=0.001）。
LG-MALT 的病程取决于 HP 根除治疗。治疗成功可促进淋巴瘤缓解。
