Office of Research on Women's Health, National Institutes of Health, Bethesda, Maryland; and the Ludeman Family Center for Women's Health Research, Department of Medicine, University of Colorado Anschutz School of Medicine, Aurora, Colorado.
Obstet Gynecol. 2022 Jul 1;140(1):10-19. doi: 10.1097/AOG.0000000000004821. Epub 2022 Jun 7.
The health of women remains understudied. In response to a request from Congress, the Office of Research on Women's Health of the National Institutes of Health (NIH) evaluated research on the health of women currently underway related to 1) rising rates of maternal morbidity and mortality, 2) rising rates of chronic debilitating conditions in women, and 3) stagnant cervical cancer survival rates. Input on the three priority areas was obtained from experts in women's health, members of the public, and federal stakeholders. The NIH research portfolios on these three topics were reviewed. On October 20, 2021, a conference on advancing NIH research on women's health was held to present, discuss, and delineate gaps and opportunities in the current portfolio. Across the life course, significant gaps in evidence regarding conditions, disorders, and diseases that occur in women were illustrated. Fundamental basic and translational knowledge gaps in many female-specific conditions and diseases with sex-specific presentations, symptoms, or responses to treatments have hampered the generation of robust scientific data needed to provide high-quality, evidence-based care to women. Key opportunities identified to improve the health of women include enhanced implementation of existing best practices and interventions to reduce disparities. Undertaking intentional clinical research on the health of women will produce significant returns on investment and has the potential to greatly improve human health.
女性健康仍未得到充分研究。应美国国会的要求，美国国立卫生研究院（NIH）下属妇女健康研究办公室评估了目前正在进行的与以下三个方面有关的女性健康研究：1）孕产妇发病率和死亡率上升；2）女性慢性衰弱性疾病发病率上升；3）宫颈癌生存率停滞不前。妇女健康专家、公众和联邦利益攸关方对这三个优先领域提供了意见。审查了 NIH 在这三个主题上的研究组合。2021 年 10 月 20 日，举行了一次关于推进 NIH 妇女健康研究的会议，以展示、讨论和阐明当前投资组合中的差距和机会。在整个生命过程中，女性特有的疾病和病症的证据存在显著差距。许多女性特有的疾病和病症在表现、症状或对治疗的反应方面存在着根本的基础和转化知识差距，这阻碍了生成提供高质量、基于证据的女性护理所需的强大科学数据。确定的改善女性健康的主要机会包括加强实施现有的最佳实践和干预措施，以减少差距。对女性健康进行有针对性的临床研究将带来显著的投资回报，并有可能极大地改善人类健康。
