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交联透明质酸用于唇腭裂美学矫正:初步报告

Cross-Linked Hyaluronic Acid for Cleft Lip and Palate Aesthetic Correction: A Preliminary Report.

作者信息

Ordynowski Łukasz

机构信息

Dr Ordynowski is an aesthetic practitioner in private practice, Kraków, Poland.

出版信息

Aesthet Surg J Open Forum. 2022 Jun 8;4:ojac052. doi: 10.1093/asjof/ojac052. eCollection 2022.

DOI:10.1093/asjof/ojac052
PMID:35854874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9280522/
Abstract

BACKGROUND

Surgical treatment of cleft lip and palate is divided into primary and secondary procedures to restore physiological function and appearance of the face, mouth, and nose. Hyaluronic acid (HA) bio-implants have been successfully used for volume loss correction in several medical disciplines. However, there is paucity of information about its use in the management of facial clefting.

OBJECTIVES

The aim of this report is to present the preliminary findings on the feasibility of using a cross-linked HA for aesthetic correction in previously surgical treated cleft lip and palate cases.

METHODS

The cross-linked HA STYLAGE L, XL, and XXL (LABORATOIRES VIVACY, Paris, France) were used in this case series. Multiple treatment sessions, 4-6 weeks apart, were performed if required.

RESULTS

A total of 15 patients had undergone the HA injections between May 2018 and December 2021. Of these, 13 had simultaneous correction of the nose, lip, and paranasal scar and the remaining 2 only the lip and scar. The procedures were uneventful and well tolerated by the patients. At follow-up, aesthetic improvement was observed in all patients. Moreover, patients reported overall satisfaction with the outcome of the procedures particularly because of its minimally invasive nature.

CONCLUSIONS

Cross-linked HA is a feasible and promising complimentary option for aesthetic, and potentially functional, correction in cases of cleft lip and palate. Larger clinical trials are needed to validate these preliminary findings.

摘要

背景

唇腭裂的外科治疗分为一期和二期手术,以恢复面部、口腔和鼻子的生理功能及外观。透明质酸(HA)生物植入物已成功应用于多个医学领域的容量缺失矫正。然而,关于其在唇腭裂治疗中的应用信息较少。

目的

本报告旨在介绍使用交联透明质酸对既往接受过手术治疗的唇腭裂病例进行美学矫正的可行性初步研究结果。

方法

本病例系列使用了交联透明质酸STYLAGE L、XL和XXL(法国巴黎VIVACY实验室)。如有需要,每隔4 - 6周进行多次治疗。

结果

2018年5月至2021年12月期间,共有15例患者接受了透明质酸注射。其中,13例同时对鼻子、嘴唇和鼻旁瘢痕进行了矫正,其余2例仅对嘴唇和瘢痕进行了矫正。手术过程顺利,患者耐受性良好。随访时,所有患者均有美学改善。此外,患者对手术结果总体满意,尤其是因其微创性。

结论

交联透明质酸是唇腭裂美学矫正以及潜在功能矫正的一种可行且有前景的辅助选择。需要更大规模的临床试验来验证这些初步研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04c8/9280522/dd025b1880d7/ojac052_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04c8/9280522/426fd03bd1f8/ojac052_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04c8/9280522/c8cf853a0311/ojac052_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04c8/9280522/dd025b1880d7/ojac052_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04c8/9280522/426fd03bd1f8/ojac052_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04c8/9280522/c8cf853a0311/ojac052_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04c8/9280522/dd025b1880d7/ojac052_fig3.jpg

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引用本文的文献

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Commentary on: Cross-linked Hyaluronic Acid for Cleft Lip and Palate Aesthetic Correction: A Preliminary Report.关于《交联透明质酸用于唇腭裂美学矫正:初步报告》的述评
Aesthet Surg J Open Forum. 2022 Aug 18;4:ojac069. doi: 10.1093/asjof/ojac069. eCollection 2022.

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Concepts of Facial Aesthetics When Considering Ethnic Rhinoplasty.考虑种族鼻整形术时的面部美学概念。
Otolaryngol Clin North Am. 2020 Apr;53(2):195-208. doi: 10.1016/j.otc.2019.12.001. Epub 2020 Jan 31.
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Lipofilling in patients with a cleft lip (and palate) - a pilot study assessing functional outcomes and patients' satisfaction with appearance.唇裂(伴或不伴腭裂)患者的脂肪填充——一项评估功能结果及患者对外观满意度的初步研究
Int J Pediatr Otorhinolaryngol. 2020 Jan;128:109692. doi: 10.1016/j.ijporl.2019.109692. Epub 2019 Sep 20.
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Effects of cleft lip and palate on children's psychological health: A systematic review.唇腭裂对儿童心理健康的影响:一项系统评价。
J Taibah Univ Med Sci. 2018 Jun 5;13(4):311-318. doi: 10.1016/j.jtumed.2018.04.007. eCollection 2018 Aug.
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The Surgical Lips Deformity Corrected with Hyaluronic Fillers: A Case Report.用透明质酸填充剂矫正唇部手术畸形:病例报告
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