Séguin P, Allard A, Cartier A, Malo J L
J Occup Med. 1987 Apr;29(4):340-4.
The prevalence of occupational asthma was assessed in four paint shops of a large assembly plant where 51 employees were exposed to several types of isocyanates, including polymethylene polyphenylisocyanate (PPI). Three employees were first referred by their physician for asthma symptoms. A questionnaire was administered to the other 48 employees. Seven of these were suspected of having work-related asthma. Airway hyperexcitability to inhaled histamine was demonstrated in these ten subjects (three referred and seven screened). The diagnosis of occupational asthma was confirmed in six subjects (three referred and three screened) through specific inhalation challenges in the laboratory to a paint system component containing PPI. Thus, the prevalence of occupational asthma was 11.8% in these paint shops using several types of isocyanates, including PPI.
在一家大型装配厂的四个喷漆车间评估职业性哮喘的患病率，该工厂有51名员工接触多种异氰酸酯，包括多亚甲基多苯基异氰酸酯（PPI）。三名员工因哮喘症状首先被其医生转诊。对其他48名员工进行了问卷调查。其中七人被怀疑患有与工作相关的哮喘。这10名受试者（三名转诊者和七名筛查者）表现出气道对吸入组胺的高反应性。通过在实验室对含有PPI的油漆系统成分进行特异性吸入激发试验，确诊了6名受试者（三名转诊者和三名筛查者）患有职业性哮喘。因此，在这些使用包括PPI在内多种异氰酸酯的喷漆车间中，职业性哮喘的患病率为11.8%。
