Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Angew Chem Int Ed Engl. 2022 Oct 24;61(43):e202207752. doi: 10.1002/anie.202207752. Epub 2022 Sep 12.
Dynamic covalent chemistry (DCC) is fascinating because of its dual nature. It perfectly combines the reversible nature of noncovalent bonds with the robustness of covalent bonds, effectively enhancing the stability of assemblies and meanwhile giving rise to unprecedented properties. Therefore, integration of DCC with supramolecular chemistry has emerged as a versatile and an extraordinarily useful approach in directing peptide assembly. This Minireview focuses on a recent strategy, which exploits dynamic Schiff base chemistry in combination with supramolecular chemistry, to mediate dipeptide assembly toward nanoarchitectonics. Diversified structures, new emergent properties, and their related applications are highlighted. Lastly, the opportunities and prospects in this exciting field are also introduced.
动态共价化学（DCC）之所以引人入胜，是因为它具有双重性质。它将非共价键的可逆性与共价键的坚固性完美结合，有效地提高了组装体的稳定性，同时赋予了前所未有的性质。因此，将 DCC 与超分子化学结合已成为指导肽组装的一种通用且非常有用的方法。这篇综述聚焦于一种新策略，该策略利用动态席夫碱化学与超分子化学相结合，来介导二肽的组装以构建纳米结构。突出了多样化的结构、新出现的性质及其相关应用。最后，还介绍了这个令人兴奋的领域的机遇和前景。
