National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
Adv Drug Deliv Rev. 2022 Oct;189:114447. doi: 10.1016/j.addr.2022.114447. Epub 2022 Jul 19.
Nanomedicines overcome the pharmacokinetic limitations of traditional drug formulations and have promising prospect in cancer treatment. However, nanomedicine delivery in vivo is still facing challenges from the complex physiological environment. For the purpose of effective tumor therapy, they should be designed to guarantee the five features principle, including long blood circulation, efficient tumor accumulation, deep matrix penetration, enhanced cell internalization and accurate drug release. To ensure the excellent performance of the designed nanomedicine, it would be better to monitor the drug delivery process as well as the therapeutic effects by real-time imaging. In this review, we summarize strategies in developing nanomedicines for efficiently meeting the five features of drug delivery, and the role of several imaging modalities (fluorescent imaging (FL), magnetic resonance imaging (MRI), computed tomography (CT), photoacoustic imaging (PAI), positron emission tomography (PET), and electron microscopy) in tracing drug delivery and therapeutic effect in vivo based on five features principle.
纳米医学克服了传统药物制剂的药代动力学限制，在癌症治疗方面具有广阔的前景。然而，纳米医学在体内的输送仍然面临着复杂生理环境带来的挑战。为了实现有效的肿瘤治疗，纳米医学应该被设计成能够保证五个特征原则，包括长血液循环、高效肿瘤积累、深层基质渗透、增强细胞内化和准确药物释放。为了确保设计的纳米医学的优异性能，最好通过实时成像来监测药物输送过程和治疗效果。在这篇综述中，我们总结了开发纳米医学的策略，以有效地满足药物输送的五个特征，以及几种成像方式（荧光成像（FL）、磁共振成像（MRI）、计算机断层扫描（CT）、光声成像（PAI）、正电子发射断层扫描（PET）和电子显微镜）在基于五个特征原则的体内药物输送和治疗效果追踪中的作用。
