Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Baniahmad Aria, Branicki Wojciech, Taheri Mohammad, Eghbali Ahmad
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Cell Dev Biol. 2022 Jul 5;10:869011. doi: 10.3389/fcell.2022.869011. eCollection 2022.
Senescence is defined as a gradual weakening of functional features of a living organism. Cellular senescence is a process that is principally aimed to remove undesirable cells by prompting tissue remodeling. This process is also regarded as a defense mechanism induced by cellular damage. In the course of oncogenesis, senescence can limit tumor progression. However, senescence participates in the pathoetiology of several disorders such as fibrotic disorders, vascular disorders, diabetes, renal disorders and sarcopenia. Recent studies have revealed contribution of different classes of non-coding RNAs in the cellular senescence. Long non-coding RNAs, microRNAs and circular RNAs are three classes of these transcripts whose contributions in this process have been more investigated. In the current review, we summarize the available literature on the impact of these transcripts in the cellular senescence.
衰老被定义为生物体功能特征的逐渐衰退。细胞衰老主要是一个通过促进组织重塑来清除不良细胞的过程。这个过程也被视为由细胞损伤诱导的一种防御机制。在肿瘤发生过程中，衰老可以限制肿瘤进展。然而，衰老参与了多种疾病的病理病因，如纤维化疾病、血管疾病、糖尿病、肾脏疾病和肌肉减少症。最近的研究揭示了不同类别的非编码RNA在细胞衰老中的作用。长链非编码RNA、微小RNA和环状RNA是这些转录本中的三类，它们在这一过程中的作用得到了更多研究。在本综述中，我们总结了关于这些转录本对细胞衰老影响的现有文献。
