新瓜蟾素 A-H，海洋来源真菌 FS685 中的 Phomactin 二萜衍生物。
Neocucurbols A-H, Phomactin Diterpene Derivatives from the Marine-Derived Fungus FS685.
机构信息
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
出版信息
J Nat Prod. 2022 Aug 26;85(8):1967-1975. doi: 10.1021/acs.jnatprod.2c00249. Epub 2022 Jul 22.
Neocucurbols A-D (-) are diterpene derivatives that possess a complex 6/6/5/5/6 polycyclic ring system with a characteristic tetrahedrofuran bridge ring skeleton. Neocucurbols E-H (-) are diterpenes that feature a 6/8/6 tricyclic ring system. Their structures were unambiguously determined by detailed spectroscopic analyses, X-ray diffractions studies, and ECD calculations. All compounds (-) were evaluated for in vitro antimicrobial and cytotoxic activities.
新瓜环 A-D(-) 是具有复杂 6/6/5/5/6 多环体系和特征四面体呋喃桥环骨架的二萜衍生物。新瓜环 E-H(-) 是具有 6/8/6 三环体系的二萜。它们的结构通过详细的光谱分析、X 射线衍射研究和 ECD 计算得以明确确定。所有化合物(-)都进行了体外抗菌和细胞毒性活性评估。
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