Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go F. Vito 1, Rome 00168, Italy.
Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go F. Vito 1, Rome 00168, Italy.
Clin Geriatr Med. 2022 Aug;38(3):473-481. doi: 10.1016/j.cger.2022.03.003. Epub 2022 Mar 21.
Severe coronavirus disease 2019 (COVID-19) is associated with overproduction of proinflammatory cytokines. The ensuing cytokine storm contributes to the development of severe pneumonia and, possibly, to long-term symptom persistence (long COVID). The chronic state of low-grade inflammation that accompanies aging (inflammaging) might predispose older adults to severe COVID-19. Inflammaging may also contribute to symptom persistence following acute COVID-19. Antiinflammatory drugs and immunomodulatory agents can achieve significant therapeutic gain during acute COVID-19. Lifestyle interventions (eg, physical activity, diet) may be proposed as strategies to counteract inflammation and mitigate long-term symptom persistence.
严重的 2019 年冠状病毒病（COVID-19）与促炎细胞因子的过度产生有关。随之而来的细胞因子风暴导致严重肺炎的发展，并可能导致长期症状持续存在（长 COVID）。衰老伴随的低度炎症的慢性状态（炎症衰老）可能使老年人易患严重的 COVID-19。炎症衰老也可能导致急性 COVID-19 后症状持续存在。在急性 COVID-19 期间，抗炎药物和免疫调节药物可以获得显著的治疗效果。生活方式干预（例如，体育活动、饮食）可以作为对抗炎症和减轻长期症状持续存在的策略。
