Sharma Praveen, Dwivedi Shailendra, Tiwari Sunita, Singh Pankaj Kumar, Pal Amit, Kumar Sandeep
Department of Biochemistry, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh 229405 India.
Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan 342005 India.
Indian J Clin Biochem. 2022 Jul;37(3):267-274. doi: 10.1007/s12291-021-01018-4. Epub 2022 Jan 14.
Diabetic Retinopathy (DR), a debilitating microvascular complication of diabetes, is one of the leading cause of blindness. However, the pathogenesis of this disease is not fully understood. Few Studies have reported the role of MicroRNA (miRNA), which is deregulated or altered in many diseases. Further, few pathways linked genes which have been suggested to be regulated by miRNAs, may play an important role in the regulation of glucose homeostasis and eventually may contribute to the establishment of DR. However, the roles of microRNAs (miRNAs) in DR are still not very clear. In current review, we explored various findings of scientific database demonstrating the role of miRNA in the progression and development of Diabetic Retinopathy.
糖尿病视网膜病变（DR）是糖尿病一种使人衰弱的微血管并发症，是导致失明的主要原因之一。然而，这种疾病的发病机制尚未完全明确。很少有研究报道微小RNA（miRNA）的作用，其在许多疾病中失调或发生改变。此外，很少有与基因相关的通路被认为受miRNA调控，这些通路可能在葡萄糖稳态调节中起重要作用，并最终可能导致糖尿病视网膜病变的发生。然而，微小RNA（miRNAs）在糖尿病视网膜病变中的作用仍不是很清楚。在当前的综述中，我们探讨了科学数据库的各种研究结果，以证明miRNA在糖尿病视网膜病变进展和发展中的作用。
