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IL-18/IL-18R 信号传导对于 ILC 发育是可有可无的，但限制了 ILCP/ILCs 的生长。

IL-18/IL-18R Signaling Is Dispensable for ILC Development But Constrains the Growth of ILCP/ILCs.

机构信息

Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Chinese Academy of Sciences (CAS) Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

出版信息

Front Immunol. 2022 Jul 8;13:923424. doi: 10.3389/fimmu.2022.923424. eCollection 2022.

DOI:10.3389/fimmu.2022.923424
PMID:35874724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9304618/
Abstract

Innate lymphoid cells (ILCs) develop from ILC progenitors in the bone marrow. Various ILC precursors (ILCPs) with different ILC subset lineage potentials have been identified based on the expression of cell surface markers and ILC-associated key transcription factor reporter genes. This study characterized an interleukin (IL)-7RαIL-18Rα ILC progenitor population in the mouse bone marrow with multi-ILC lineage potential on the clonal level. Single-cell gene expression analysis revealed the heterogeneity of this population and identified several subpopulations with specific ILC subset-biased gene expression profiles. The role of IL-18 signaling in the regulation of IL-18Rα ILC progenitors and ILC development was further investigated using and deficient mice, differentiation assay, and adoptive transfer model. IL-18/IL-18R-mediated signal was found to not be required for early stages of ILC development. While lymphoid progenitors were able to generate all ILC subsets and like the wild-type counterpart, increased IL-18 level, as often occurred during infection or under stress, suppressed the growth of ILCP/ILC in an IL-18Ra-dependent manner inhibiting proliferation and inducing apoptosis.

摘要

先天淋巴细胞 (ILC) 由骨髓中的 ILC 祖细胞发育而来。基于细胞表面标志物和 ILC 相关关键转录因子报告基因的表达，已经鉴定出各种具有不同 ILC 亚群分化潜能的 ILC 前体 (ILCP)。本研究在小鼠骨髓中鉴定出一种具有多种 ILC 谱系潜能的 IL-7RαIL-18Rα ILC 祖细胞群体，在克隆水平上具有多 ILC 谱系潜能。单细胞基因表达分析揭示了该群体的异质性，并确定了具有特定 ILC 亚群偏向基因表达谱的几个亚群。使用 和缺陷小鼠、 分化测定和过继转移模型进一步研究了 IL-18 信号在调节 IL-18Rα ILC 祖细胞和 ILC 发育中的作用。发现 IL-18/IL-18R 介导的信号对于 ILC 发育的早期阶段不是必需的。虽然 淋巴祖细胞能够产生所有的 ILC 亚群， 和野生型一样，但增加的 IL-18 水平，如在感染或应激下经常发生的那样，以 IL-18Ra 依赖的方式抑制 ILCP/ILC 的生长， 抑制增殖并诱导细胞凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/e1dcec57aef2/fimmu-13-923424-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/3bb81dbfd3cd/fimmu-13-923424-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/d179c34a02a4/fimmu-13-923424-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/332717ede34f/fimmu-13-923424-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/0b2f1b17bc7e/fimmu-13-923424-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/0afdead3eefe/fimmu-13-923424-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/aeb4bc315295/fimmu-13-923424-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/e1dcec57aef2/fimmu-13-923424-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/3bb81dbfd3cd/fimmu-13-923424-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/d179c34a02a4/fimmu-13-923424-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/332717ede34f/fimmu-13-923424-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/0b2f1b17bc7e/fimmu-13-923424-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/0afdead3eefe/fimmu-13-923424-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/aeb4bc315295/fimmu-13-923424-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd9/9304618/e1dcec57aef2/fimmu-13-923424-g007.jpg

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本文引用的文献

1
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J Exp Med. 2022 Feb 7;219(2). doi: 10.1084/jem.20211406. Epub 2021 Dec 17.
2
IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock.IL-18R 介导体细胞静止和 MLKL 依赖性细胞死亡限制感染诱导性休克期间的造血。
Stem Cell Reports. 2021 Dec 14;16(12):2887-2899. doi: 10.1016/j.stemcr.2021.10.011. Epub 2021 Nov 18.
3
Innate lymphoid cell development.
生物钟控制的内分泌和细胞因子信号调节骨髓中的多能先天淋巴样细胞祖细胞。
Cell Rep. 2024 May 28;43(5):114200. doi: 10.1016/j.celrep.2024.114200. Epub 2024 May 7.
4
Innate Lymphoid Cell Plasticity in Mucosal Infections.黏膜感染中固有淋巴细胞的可塑性
Microorganisms. 2023 Feb 12;11(2):461. doi: 10.3390/microorganisms11020461.
固有淋巴细胞发育
J Allergy Clin Immunol. 2021 May;147(5):1549-1560. doi: 10.1016/j.jaci.2021.03.009.
4
Transcription Factor Bhlhe40 in Immunity and Autoimmunity.转录因子 Bhlhe40 在免疫和自身免疫中的作用。
Trends Immunol. 2020 Nov;41(11):1023-1036. doi: 10.1016/j.it.2020.09.002. Epub 2020 Oct 7.
5
In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.2 型先天淋巴细胞祖细胞的原位成熟和组织适应。
Immunity. 2020 Oct 13;53(4):775-792.e9. doi: 10.1016/j.immuni.2020.09.002. Epub 2020 Sep 30.
6
Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.组织特异性途径将激活的 ILC2 逐出以传播 2 型免疫。
J Exp Med. 2020 Apr 6;217(4). doi: 10.1084/jem.20191172.
7
Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker.先天淋巴细胞中的白细胞介素-7 受体 α：不仅仅是一个标志物。
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8
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Nat Immunol. 2019 Sep;20(9):1150-1160. doi: 10.1038/s41590-019-0445-7. Epub 2019 Jul 29.