海洋来源细菌来源的新型糖基化次生代谢产物。

New Glycosylated Secondary Metabolites from Marine-Derived Bacteria.

机构信息

Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea.

Department of Marine Biotechnology, University of Science and Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon 34113, Korea.

出版信息

Mar Drugs. 2022 Jul 20;20(7):464. doi: 10.3390/md20070464.

DOI:10.3390/md20070464

PMID:35877757

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9321207/

Abstract

Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (), and two new trehalose lipids ( and ), together with three known compounds (-) were isolated from two marine-derived bacterial strains, 168CLC-66.1 and IV19-045. The structures of - were determined by extensive analysis and comparison of their spectroscopic data with literature values. The absolute configurations of sugar moieties were determined by chemical derivatization followed by LC-MS analysis. Cytotoxicity of - against six cancer cell lines was evaluated by SRB assay, and showed moderate activity against all the tested cell lines with GI values ranging from 8.0 to 10.9 µM.

摘要

从两株海洋来源的细菌菌株 168CLC-66.1 和 IV19-045 中分离得到了三个新的糖基化次生代谢产物，包括一个新的吲哚生物碱 pityriacitrin D () 和两个新的海藻糖脂 () 和 ()，以及三个已知化合物 (-)。通过与文献值的光谱数据的广泛分析和比较，确定了 - 的结构。通过化学衍生化和 LC-MS 分析确定了糖部分的绝对构型。通过 SRB 测定法评估了 - 对六种癌细胞系的细胞毒性，结果表明，对所有测试的细胞系均显示出中等活性，GI 值范围为 8.0 至 10.9 μM。