Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro Yuseong-gu, Daejeon 34113, Korea.
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea.
Mar Drugs. 2019 Apr 20;17(4):237. doi: 10.3390/md17040237.
Three new hydroxylated rhamnolipids, dokdolipids A-C (-) were obtained from the marine actinomycete , which was isolated from a sediment sample collected off the coasts of Dokdo island, Republic of Korea. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR and mass spectrometric data analyses. Their absolute configurations were assigned using the modified Mosher's method and specific rotation values, as well as acid hydrolysis, chemical derivatizations and subsequent HPLC analysis to determine the configuration of the sugar moieties. All new compounds were evaluated for their cytotoxicity against six cancer cell lines, HCT-15, NUGC-3, NCI-H23, ACHN, PC-3 and MDA-MB-231. Compounds - displayed moderate cytotoxicity against all the cell lines tested with IC values ranging from 13.7-41.5 µM.
从海洋放线菌中分离得到三种新的羟基化鼠李糖脂 dokdolipids A-C(-)，该放线菌是从韩国独岛(Dokdo island)海域的沉积物样本中分离得到的。根据 1D 和 2D NMR 以及质谱数据分析，确定了分离化合物的结构。使用改进的 Mosher 法和比旋光度以及酸水解、化学衍生化和随后的 HPLC 分析来确定糖部分的构型，从而确定了它们的绝对构型。所有新化合物均针对其对六种癌细胞系 HCT-15、NUGC-3、NCI-H23、ACHN、PC-3 和 MDA-MB-231 的细胞毒性进行了评估。化合物-对所有测试的细胞系均表现出中等的细胞毒性，IC 值范围为 13.7-41.5 µM。
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