Tantillo Tyler J, Chang Kevin, Tan Sean, Sirotnikov Sam, Goodman Howard J
Department of Orthopaedic Surgery, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, Huntington Hospital, Huntington, NY.
New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY.
J Hand Surg Glob Online. 2022 May 25;4(4):233-238. doi: 10.1016/j.jhsg.2022.04.010. eCollection 2022 Jul.
In this case report, we describe a novel occurrence of tumoral calcium pyrophosphate dihydrate crystal deposition disease (TCPPDCD) in a 76-year-old man that presented as an unusual, intraosseous, metadiaphyseal lesion of a long bone causing a pathologic fracture. A routine intralesional biopsy was performed, demonstrating granular deposits composed of polarizing, overlapping rhomboid crystals consistent with TCPPDCD. With limited numbers of reported cases of TCPPDCD, and the atypical intraosseous origin seen in this case, it is paramount to thoroughly evaluate all cases of TCPPDCD to clearly differentiate key findings that are essential in diagnosing and managing TCPPDCD.
在本病例报告中，我们描述了一名76岁男性发生的新型肿瘤性焦磷酸钙二水合物晶体沉积病（TCPPDCD），其表现为长骨骨干中段不寻常的骨内病变，导致病理性骨折。进行了常规的病变内活检，显示出由偏振、重叠的菱形晶体组成的颗粒状沉积物，与TCPPDCD一致。鉴于TCPPDCD的报告病例数量有限，且本病例中出现非典型的骨内起源，对所有TCPPDCD病例进行全面评估以明确区分诊断和管理TCPPDCD所需的关键发现至关重要。
