• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

波兰蜂胶和新西兰蜂胶作为抗氧化化合物的来源，可抑制胶质母细胞瘤（T98G、LN - 18）细胞系以及源自患者的星形细胞瘤细胞。

Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient.

作者信息

Moskwa Justyna, Naliwajko Sylwia Katarzyna, Markiewicz-Żukowska Renata, Gromkowska-Kępka Krystyna Joanna, Soroczyńska Jolanta, Puścion-Jakubik Anna, Borawska Maria Halina, Isidorov Valery, Socha Katarzyna

机构信息

Department of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, Poland.

Forest Faculty, Białystok University of Technology, Wiejska 45A Street, 15-351 Białystok, Poland.

出版信息

Antioxidants (Basel). 2022 Jun 29;11(7):1305. doi: 10.3390/antiox11071305.

DOI:10.3390/antiox11071305
PMID:35883797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9312157/
Abstract

Gliomas, including glioblastoma multiforme and astrocytoma, are common brain cancers in adults. Propolis is a natural product containing many active ingredients. The aim of this study was to compare the chemical composition, total phenolic content and concentration of toxic elements as well as the anticancer potential of Polish (PPE) and New Zealand (Manuka-MPE) propolis extracts on diffuse astrocytoma derived from patient (DASC) and glioblastoma (T98G, LN-18) cell lines. The antioxidants such as flavonoids and chalcones (pinocembrin, pinobanksin, pinobanksin 3-acetate and chrysin) were the main components in both types of propolis. The content of arsenic (As) and lead (Pb) in MPE was higher than PPE. The anti-proliferative study showed strong activity of PPE and MPE propolis on DASC, T98G, and LN-18 cells by apoptosis induction, cell cycle arrest and attenuated migration. These findings suggest that despite their different geographic origins, Polish and New Zealand propolis are sources of antioxidant compounds and show similar activity and a promising anti-glioma potential in in vitro study. However, further in vivo studies are required in order to assess therapeutic potential of propolis.

摘要

胶质瘤，包括多形性胶质母细胞瘤和星形细胞瘤，是成人常见的脑癌。蜂胶是一种含有多种活性成分的天然产物。本研究的目的是比较波兰蜂胶（PPE）和新西兰麦卢卡蜂胶（Manuka-MPE）提取物的化学成分、总酚含量和有毒元素浓度，以及它们对源自患者的弥漫性星形细胞瘤（DASC）和胶质母细胞瘤（T98G、LN-18）细胞系的抗癌潜力。黄酮类化合物和查耳酮（松属素、白杨素、白杨素3-乙酸酯和 Chrysin）等抗氧化剂是两种蜂胶的主要成分。MPE中砷（As）和铅（Pb）的含量高于PPE。抗增殖研究表明，PPE和MPE蜂胶通过诱导凋亡、细胞周期阻滞和减弱迁移，对DASC、T98G和LN-18细胞具有很强的活性。这些发现表明，尽管波兰蜂胶和新西兰蜂胶的地理来源不同，但它们都是抗氧化化合物的来源，并且在体外研究中显示出相似的活性和有前景的抗胶质瘤潜力。然而，需要进一步的体内研究来评估蜂胶的治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/fa51821db98f/antioxidants-11-01305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/864b1ce67af5/antioxidants-11-01305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/711b36095da2/antioxidants-11-01305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/e7b24baafe50/antioxidants-11-01305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/d06f0f6be160/antioxidants-11-01305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/fa51821db98f/antioxidants-11-01305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/864b1ce67af5/antioxidants-11-01305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/711b36095da2/antioxidants-11-01305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/e7b24baafe50/antioxidants-11-01305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/d06f0f6be160/antioxidants-11-01305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cf/9312157/fa51821db98f/antioxidants-11-01305-g005.jpg

相似文献

1
Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient.波兰蜂胶和新西兰蜂胶作为抗氧化化合物的来源，可抑制胶质母细胞瘤（T98G、LN - 18）细胞系以及源自患者的星形细胞瘤细胞。
Antioxidants (Basel). 2022 Jun 29;11(7):1305. doi: 10.3390/antiox11071305.
2
Chemical composition of Polish propolis and its antiproliferative effect in combination with Bacopa monnieri on glioblastoma cell lines.波兰蜂胶的化学成分及其与益智草联合对神经胶质瘤细胞系的抗增殖作用。
Sci Rep. 2020 Dec 3;10(1):21127. doi: 10.1038/s41598-020-78014-w.
3
Antiproliferative activity of New Zealand propolis and phenolic compounds vs human colorectal adenocarcinoma cells.新西兰蜂胶和酚类化合物对人结肠腺癌细胞的抗增殖活性。
Fitoterapia. 2015 Oct;106:167-74. doi: 10.1016/j.fitote.2015.09.004. Epub 2015 Sep 6.
4
Botanical Origins and Antioxidant Activities of Two Types of Flavonoid-Rich Poplar-Type Propolis.两种富含黄酮类化合物的杨树型蜂胶的植物来源及抗氧化活性
Foods. 2023 Jun 7;12(12):2304. doi: 10.3390/foods12122304.
5
Effect of Ethanol/Water Solvents on Phenolic Profiles and Antioxidant Properties of Beijing Propolis Extracts.乙醇/水溶剂对北京蜂胶提取物酚类成分及抗氧化性能的影响
Evid Based Complement Alternat Med. 2015;2015:595393. doi: 10.1155/2015/595393. Epub 2015 Aug 17.
6
Effect of the Solvent on Propolis Phenolic Profile and its Antifungal, Antioxidant, and In Vitro Cytoprotective Activity in Human Erythrocytes Under Oxidative Stress.溶剂对蜂胶酚类成分的影响及其在氧化应激下人红细胞中的抗真菌、抗氧化和体外细胞保护活性。
Molecules. 2020 Sep 17;25(18):4266. doi: 10.3390/molecules25184266.
7
Evaluation of Chemical Composition, Sun Protection Factor and Antioxidant Activity of Lithuanian Propolis and Its Plant Precursors.立陶宛蜂胶及其植物源前体的化学成分、防晒系数和抗氧化活性评估。
Plants (Basel). 2022 Dec 16;11(24):3558. doi: 10.3390/plants11243558.
8
Anti-proliferative and anti-migration effects of Polish propolis combined with Hypericum perforatum L. on glioblastoma multiforme cell line U87MG.波兰蜂胶与贯叶连翘联用对多形性胶质母细胞瘤细胞系U87MG的抗增殖和抗迁移作用
BMC Complement Altern Med. 2016 Sep 20;16:367. doi: 10.1186/s12906-016-1351-2.
9
Antioxidant compounds of propolis determined by capillary electrophoresis-mass spectrometry.采用毛细管电泳-质谱联用技术测定蜂胶中的抗氧化化合物。
J Sep Sci. 2007 Mar;30(4):595-603. doi: 10.1002/jssc.200600354.
10
Grouping, Spectrum-Effect Relationship and Antioxidant Compounds of Chinese Propolis from Different Regions Using Multivariate Analyses and Off-Line Anti-DPPH Assay.基于多元分析和离线抗 DPPH 测定的不同地区中国蜂胶的分组、谱效关系和抗氧化成分。
Molecules. 2020 Jul 16;25(14):3243. doi: 10.3390/molecules25143243.

引用本文的文献

1
Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic -Induced Colitis and Tumorigenesis.没食子酸苯乙酯给药可减轻肠毒素诱导的结肠炎和肿瘤发生。
Toxins (Basel). 2024 Sep 18;16(9):403. doi: 10.3390/toxins16090403.

本文引用的文献

1
Evaluation of Blood-Brain Barrier Permeability of Polyphenols, Anthocyanins, and Their Metabolites.多酚、花色苷及其代谢产物的血脑屏障通透性评价。
J Agric Food Chem. 2021 Oct 6;69(39):11676-11686. doi: 10.1021/acs.jafc.1c02898. Epub 2021 Sep 23.
2
Biological Impact of Phenolic Compounds from Coffee on Colorectal Cancer.咖啡中酚类化合物对结直肠癌的生物学影响
Pharmaceuticals (Basel). 2021 Aug 3;14(8):761. doi: 10.3390/ph14080761.
3
Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook.
胶质母细胞瘤治疗中的天然化合物：临床前见解、作用机制途径及展望
Cancers (Basel). 2021 May 12;13(10):2317. doi: 10.3390/cancers13102317.
4
Multielemental Analysis of Bee Pollen, Propolis, and Royal Jelly Collected in West-Central Poland.波兰中西部地区采集的蜂花粉、蜂胶和蜂王浆的多元素分析。
Molecules. 2021 Apr 21;26(9):2415. doi: 10.3390/molecules26092415.
5
Content of Toxic Elements in 12 Groups of Rice Products Available on Polish Market: Human Health Risk Assessment.波兰市场上12种大米产品中的有毒元素含量：人体健康风险评估。
Foods. 2020 Dec 20;9(12):1906. doi: 10.3390/foods9121906.
6
Chemical composition of Polish propolis and its antiproliferative effect in combination with Bacopa monnieri on glioblastoma cell lines.波兰蜂胶的化学成分及其与益智草联合对神经胶质瘤细胞系的抗增殖作用。
Sci Rep. 2020 Dec 3;10(1):21127. doi: 10.1038/s41598-020-78014-w.
7
Single-Walled Carbon Nanotubes Attenuate Cytotoxic and Oxidative Stress Response of Pb in Human Lung Epithelial (A549) Cells.单壁碳纳米管减轻人肺上皮（A549）细胞中铅的细胞毒性和氧化应激反应。
Int J Environ Res Public Health. 2020 Nov 6;17(21):8221. doi: 10.3390/ijerph17218221.
8
Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest.中国蜂胶通过诱导细胞凋亡和细胞周期阻滞抑制人胃癌细胞增殖。
Evid Based Complement Alternat Med. 2020 Jul 22;2020:2743058. doi: 10.1155/2020/2743058. eCollection 2020.
9
The Presence of Caffeic Acid in Cerebrospinal Fluid: Evidence That Dietary Polyphenols Can Cross the Blood-Brain Barrier in Humans.脑脊液中咖啡酸的存在：饮食多酚可在人类中穿透血脑屏障的证据。
Nutrients. 2020 May 25;12(5):1531. doi: 10.3390/nu12051531.
10
The Complex Interplay between Antioxidants and ROS in Cancer.抗氧化剂与活性氧簇在癌症中的复杂相互作用。
Trends Cell Biol. 2020 Jun;30(6):440-451. doi: 10.1016/j.tcb.2020.03.002. Epub 2020 Apr 14.