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诱导骨髓间充质干细胞涂层的纤维素/胶原纳米纤维神经导管对切断面神经再生的影响。

Effect of Pre-Induced Mesenchymal Stem Cell-Coated Cellulose/Collagen Nanofibrous Nerve Conduit on Regeneration of Transected Facial Nerve.

机构信息

Department of Biology, College of Natural Science, Chosun University, Gwangju 61452, Korea.

Department of Life Science, BK21-Plus Research Team for Bioactive Control Technology, Chosun University, Gwangju 61452, Korea.

出版信息

Int J Mol Sci. 2022 Jul 11;23(14):7638. doi: 10.3390/ijms23147638.

DOI:10.3390/ijms23147638
PMID:35886987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9318960/
Abstract

(1) Objective: In order to evaluate the effect of a pre-induced mesenchymal stem cell (MSC)-coated cellulose/collagen nanofibrous nerve conduit on facial nerve regeneration in a rat model both in vitro and in vivo. (2) Methods: After fabrication of the cellulose/collagen nanofibrous conduit, its lumen was coated with either MSCs or pre-induced MSCs. The nerve conduit was then applied to the defective main trunk of the facial nerve. Rats were randomly divided into three treatment groups (n = 10 in each): cellulose/collagen nanofiber (control group), cellulose/collagen nanofiber/MSCs (group I), and cellulose/collagen nanofiber/pre-induced MSCs (group II). (3) Results Fibrillation of the vibrissae of each group was observed, and action potential threshold was compared 8 weeks post-surgery. Histopathological changes were also observed. Groups I and II showed better recovery of vibrissa fibrillation than the control group. (4) Conclusions: Group II, treated with the pre-induced MSC-coated cellulose/collagen nanofibrous nerve conduit, showed the highest degree of recovery based on functional and histological evaluations.

摘要

（1）目的：为了评估预先诱导的间充质干细胞（MSC）涂层纤维素/胶原纳米纤维神经导管在体外和体内大鼠模型中对面神经再生的影响。（2）方法：在制备纤维素/胶原纳米纤维导管后，其管腔被涂覆有 MSC 或预先诱导的 MSC。然后将神经导管应用于面神经的主要主干缺损处。大鼠被随机分为三组（每组 10 只）：纤维素/胶原纳米纤维（对照组）、纤维素/胶原纳米纤维/MSC（I 组）和纤维素/胶原纳米纤维/预先诱导的 MSC（II 组）。（3）结果：观察每组触须的颤动，并比较术后 8 周时的动作电位阈值。还观察了组织病理学变化。I 组和 II 组的触须颤动恢复情况优于对照组。（4）结论：基于功能和组织学评估，用预先诱导的 MSC 涂层纤维素/胶原纳米纤维神经导管治疗的 II 组显示出最高程度的恢复。

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