Department of Applied Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
Doctoral School of Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
Int J Mol Sci. 2022 Jul 18;23(14):7904. doi: 10.3390/ijms23147904.
In this paper, the synthesis, characterization, and properties of crosslinked poly(ε-caprolactone)-based polyurethanes as potential tissue replacement materials are reported. The polyurethane prepolymers were prepared from poly(ε-caprolactone)diol (PCD), polyethylene glycol (PEG)/polylactic acid diol (PLAD), and 1,6-hexamethylene diisocyanate (HDI). In these segmented polyurethanes, the role of PEG/PLAD was to tune the hydrophobic/hydrophilic character of the resulting polymer while sucrose served as a crosslinking agent. PLAD was synthesized by the polycondensation reaction of D,L-lactic acid and investigated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and nuclear magnetic resonance spectroscopy (NMR). The crosslinked polyurethane samples (SUPURs) obtained were characterized by attenuated total reflectance Fourier-transform infrared spectroscopy (AT-FT-IR), swelling, and mechanical (uniaxial tensile tests) experiments. The thermo and thermomechanical behavior were studied by differential scanning calorimetry (DSC) and dynamical mechanical analysis (DMA). The viability of dental pulp stem cells was investigated in the case of polyurethanes composed of fully biocompatible elements. In our studies, none of our polymers showed toxicity to stem cells (DPSCs).
本文报道了交联聚（ε-己内酯）基聚氨酯作为潜在组织替代材料的合成、表征和性能。聚氨酯预聚物由聚（ε-己内酯）二醇（PCD）、聚乙二醇（PEG）/聚乳酸二醇（PLAD）和 1,6-己二异氰酸酯（HDI）制备。在这些嵌段聚氨酯中，PEG/PLAD 的作用是调节所得聚合物的疏水性/亲水性特征，而蔗糖则作为交联剂。PLAD 通过 D,L-乳酸的缩聚反应合成，并通过基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）和核磁共振波谱（NMR）进行了研究。通过衰减全反射傅里叶变换红外光谱（AT-FT-IR）、溶胀和力学（单轴拉伸试验）实验对得到的交联聚氨酯样品（SUPURs）进行了表征。通过差示扫描量热法（DSC）和动态力学分析（DMA）研究了热和热机械性能。在由完全生物相容元素组成的聚氨酯的情况下，研究了牙髓干细胞的活力。在我们的研究中，我们的聚合物都没有显示出对干细胞（DPSCs）的毒性。
