Dwivedi Ruby, Kumar Sumit, Pandey Rahul, Mahajan Aman, Nandana Deepti, Katti Dhirendra S, Mehrotra Divya
Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, KGMU, Lucknow, UP, India.
DHR-MRU, Faculty of Dental Sciences, KGMU, Lucknow, UP, India.
J Oral Biol Craniofac Res. 2020 Jan-Mar;10(1):381-388. doi: 10.1016/j.jobcr.2019.10.003. Epub 2019 Nov 5.
Bone tissue engineering using polymer based scaffolds have been studied a lot in last decades. Considering the qualities of all the polymers desired to be used as scaffolds, Polycaprolactone (PCL) polyester apart from being biocompatible and biodegradable qualifies to an appreciable level due its easy availability, cost efficacy and suitability for modification. Its adjustable physio-chemical state, biological properties and mechanical strength renders it to withstand physical, chemical and mechanical, insults without significant loss of its properties. This review aims to critically analyse the efficacy of PCL as a biomaterial for bone scaffolds.
在过去几十年中，对使用基于聚合物的支架进行骨组织工程的研究颇多。考虑到所有期望用作支架的聚合物的特性，聚己内酯（PCL）聚酯除了具有生物相容性和可生物降解性外，因其易于获取、成本效益高以及适合改性，在相当程度上符合要求。其可调节的物理化学状态、生物学特性和机械强度使其能够承受物理、化学和机械损伤，而其性能不会有显著损失。本综述旨在批判性地分析PCL作为骨支架生物材料的有效性。
