Department of Gynecology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
China Academy of Chinese Medical Sciences, Beijing 100700, China.
Molecules. 2022 Jul 13;27(14):4476. doi: 10.3390/molecules27144476.
Polycystic ovary syndrome (PCOS) is a common multisystem disease with reproductive, metabolic and psychological abnormalities. It is characterized by a high prevalence rate in women of childbearing age and highly heterogeneous clinical manifestations, which seriously harm women's physical and mental health. Quercetin (QUR) is a natural compound of flavonoids found in a variety of foods and medicinal plants. It can intervene with the pathologic process of PCOS from multiple targets and channels and has few adverse reactions. It is mentioned in this review that QUR can improve ovulation disorder, relieve Insulin resistance (IR), reduce androgen, regulate lipid metabolism, regulate gut microbiota and improve vascular endothelial function, which is of great significance in the treatment of PCOS.
多囊卵巢综合征(PCOS)是一种常见的多系统疾病,具有生殖、代谢和心理异常。它的特点是育龄妇女的高发率和高度异质性的临床表现,严重危害妇女的身心健康。槲皮素(QUR)是一种在各种食物和药用植物中发现的类黄酮天然化合物。它可以从多个靶点和途径干预 PCOS 的病理过程,且不良反应较少。本综述提到,QUR 可以改善排卵障碍,缓解胰岛素抵抗(IR),降低雄激素,调节脂代谢,调节肠道微生物群,改善血管内皮功能,对 PCOS 的治疗具有重要意义。