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肝细胞癌中microRNA-122的分子靶点及信号通路

Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma.

作者信息

Chun Kwang-Hoon

机构信息

Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea.

出版信息

Pharmaceutics. 2022 Jun 29;14(7):1380. doi: 10.3390/pharmaceutics14071380.

DOI:10.3390/pharmaceutics14071380
PMID:35890276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9316959/
Abstract

Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality. MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein expression by suppressing translation, inducing mRNA cleavage, and promoting mRNA degradation. miR-122 is the most abundant miRNA in the liver and is responsible for several liver-specific functions, including metabolism, cellular growth and differentiation, and hepatitis virus replication. Recent studies have shown that aberrant regulation of miR-122 is a key factor contributing to the development of HCC. In this review, the signaling pathways and the molecular targets of miR-122 involved in the progression of HCC have been summarized, and the importance of miR-122 in therapy has been discussed.

摘要

肝细胞癌（HCC）是全球癌症死亡的主要原因之一。微小RNA（miRNA）是一类小干扰RNA，可通过抑制翻译、诱导mRNA切割和促进mRNA降解来降低蛋白质表达水平。miR-122是肝脏中含量最丰富的miRNA，负责多种肝脏特异性功能，包括代谢、细胞生长和分化以及肝炎病毒复制。最近的研究表明，miR-122的异常调控是导致HCC发生发展的关键因素。在本综述中，总结了miR-122参与HCC进展的信号通路和分子靶点，并讨论了miR-122在治疗中的重要性。

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