Ibrahim Ranya, Mndlovu Hillary, Kumar Pradeep, Adeyemi Samson A, Choonara Yahya E
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa.
Polymers (Basel). 2022 Jul 20;14(14):2929. doi: 10.3390/polym14142929.
There is significant interest in using stem cells in the management of cutaneous wounds. However, potential safety, efficacy, and cost problems associated with whole-cell transplantation hinder their clinical application. Secretome, a collective of mesenchymal stem-cell-stored paracrine factors, and immunomodulatory cytokines offer therapeutic potential as a cell-free therapy for the treatment of cutaneous wounds. This review explores the possibility of secretome as a treatment for cutaneous wounds and tissue regeneration. The review mainly focuses on in vitro and in vivo investigations that use biomaterials and secretome together to treat wounds, extend secretome retention, and control release to preserve their biological function. The approaches employed for the fabrication of biomaterials with condition media or extracellular vesicles are discussed to identify their future clinical application in wound treatment.
人们对使用干细胞治疗皮肤伤口有着浓厚的兴趣。然而，与全细胞移植相关的潜在安全性、有效性和成本问题阻碍了它们的临床应用。分泌组是间充质干细胞储存的旁分泌因子和免疫调节细胞因子的集合体，作为一种用于治疗皮肤伤口的无细胞疗法具有治疗潜力。本综述探讨了分泌组作为治疗皮肤伤口和组织再生方法的可能性。该综述主要关注体外和体内研究，这些研究将生物材料和分泌组联合使用来治疗伤口、延长分泌组保留时间并控制释放以保持其生物学功能。讨论了用条件培养基或细胞外囊泡制造生物材料的方法，以确定它们在伤口治疗中的未来临床应用。
