Tan Kevin Y K, Soh Alexius S E, Ong Brenda W L, Chen Mark Ic, Griva Konstadina
Population/Global Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
Infectious Disease Research and Training Office, National Centre for Infectious Diseases, 16 Jln Tan Tock Seng, Singapore 308442, Singapore.
Vaccines (Basel). 2022 Jul 6;10(7):1088. doi: 10.3390/vaccines10071088.
In response to declining vaccine-induced immunity and the emergence of new COVID-19 variants, COVID-19 booster vaccination programmes have been widely launched in several high-income countries. However, public response has been slow, and scepticism about these programmes is rising in these settings. This study sought to identify the sociodemographic, emotional, and psychological factors associated with COVID-19 booster vaccine hesitancy in Singapore. Derived from a community cohort, 1005 fully vaccinated adults (62.1% female, mean age = 42.6 years) that had not received their COVID-19 booster shots completed an online survey between October and November 2021 on vaccination beliefs, intentions, and behaviours. Results indicated that despite completing the primary COVID-19 vaccination, 30.5% of those surveyed were hesitant about receiving the booster shot (25.9% unsure; 4.7% refused the booster), and 39.2% perceived more vaccine risks than benefits. Multivariable models indicated that a tertiary education, lower COVID-19 threat perception, lower perceived benefits, higher perceived concerns, a decreased need for booster vaccination, and a lower benefit/concerns differential score were associated with higher odds of booster vaccine hesitancy. Success in the primary vaccination series may not warrant widespread public acceptance for recurrent COVID-19 vaccination doses. In addressing booster vaccine hesitancy as restrictive measures and mandates are lifted, health perceptions relevant or unique to booster vaccine uptake should be considered.
为应对疫苗诱导的免疫力下降以及新型冠状病毒病（COVID-19）变体的出现，多个高收入国家已广泛启动COVID-19加强疫苗接种计划。然而，公众反应迟缓，在这些地区，对这些计划的怀疑情绪正在上升。本研究旨在确定新加坡与COVID-19加强疫苗犹豫相关的社会人口学、情绪和心理因素。从一个社区队列中选取了1005名已完全接种疫苗但尚未接种COVID-19加强针的成年人（女性占62.1%，平均年龄=42.6岁），他们于2021年10月至11月完成了一项关于疫苗接种信念、意图和行为的在线调查。结果表明，尽管完成了COVID-19的初级疫苗接种，但30.5%的受访者对接种加强针犹豫不决（25.9%不确定；4.7%拒绝接种加强针），39.2%的人认为疫苗风险大于益处。多变量模型表明，高等教育、较低的COVID-19威胁认知、较低的感知益处、较高的感知担忧、对接种加强疫苗需求的降低以及较低的益处/担忧差异得分与加强疫苗犹豫的较高几率相关。初级疫苗接种系列的成功可能无法保证公众对反复接种COVID-19疫苗剂量的广泛接受。在解除限制措施和强制要求的情况下解决加强疫苗犹豫问题时，应考虑与加强疫苗接种相关或独特的健康认知。
